Assessment of the Magnitude and Associated Factors of Immunological Failure among Adult and Adolescent HIV-Infected Patients in St. Luke and Tulubolo Hospital, Oromia Region, Ethiopia

Below:  Cumulative probability of not developing immunological failure for patients after initiation of HAART, St.Luke and Tulu Bolo Hospital, April 2006-July 2013

Results: a total of 828 patient charts were reviewed. 477 (57.6%) were female and the median age was 32 years. The median baseline CD4 count was 148 cells/mm3. The most common prescribed ART was TDF based (36.7%). Out of 828 patients chart reviewed 6.8% (56) were developed immunological failure. Out of them only 20 (2.4%) were detected and put on second line regimen. The incidence of immunological failure was 1.8 cases per 100 person years of follow-up. Patients who had not disclosed their HIV status to any one had high risk of immunological failure compared with patients those who had disclosed their HIV status (AHR, 0.429; 95% CI 0.206 - 0.893; P-value=0.024).

Conclusion: non disclosures of HIV status and with ambulatory of baseline functional status were found to be predictors of immunological failure. Most of the immunological failure cases were not detected early and not switched to second line ARV regimen. So patients with the above risk factors should be considered for a timely switch to second line HAART.

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