Pre-Vaccination Type-Specific HPV Prevalence in Confirmed Cervical High Grade Lesions in the Māori & Non-Māori Populations in New Zealand

Below:  Age-specific prevalence of oncogenic HPV types by histology grade and ethnicity. Any HR HPV – any high risk (HR) HPV infection, regardless of co-infection with other HPV types; Any HPV 16 - HPV 16 infection, regardless of co-infection with other oncogenic HPV types; Any HPV 16 and/or 18 - HPV 16 and/or 18 infection, regardless of co-infection with other oncogenic HPV types; Other HR HPV alone - other high risk HPV infection without co-infection with HPV 16 and/or 18

In confirmed CIN2/3, the prevalence of any oncogenic HPV, HPV16 and HPV18 was 96 % (95 % CI:91–99 %), 54 % (95 % CI:46–63 %), 11 % (95 % CI:7–18 %) in Māori and 96 % (95 % CI:93–98 %), 54 % (95 % CI:48–60 %), 11 % (95 % CI:7–15 %) in non-Māori women, respectively. Age-specific patterns of infection for HPV16/18 in confirmed CIN2/3 differed between the two groups (P _interaction  = 0.02), with a lower prevalence in younger vs. older Māori women (57 % in 20–29 years vs 75 % in 40–69 years) but a higher prevalence in younger vs. older non-Māori women (70 % in 20–29 years vs 49 % in 40–69 years); the difference in the age-specific patterns of infection for HPV16/18 was not significant either when considering confirmed CIN2 alone (p = 0.09) or CIN3 alone (p = 0.22).

The overall prevalence of vaccine-included types in CIN2/3 was similar in Māori and non-Māori women, implying that the long-term effects of vaccination will be similar in the two groups.

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