Suboptimal viral suppression and CD4 response to
antiretroviral treatment (HAART) is known to cause poor outcomes with the
increase cost of treatment. We aimed to assess factors associated with such
control among HIV/AIDS patients in Malaysia.
Four hundred and six HIV/AIDS patients, using Antiretroviral
Therapy (ART) for at least the past three months, treated as outpatients at
medication therapy adherence clinics (MTAC) were recruited. CD4 cell counts,
viral load readings along with co-variants such as socio-demographic factors,
adverse drug reactions, comorbidities and medication record were obtained.
Statistical Package for Social Sciences (SPSS®) version 18 and STATA IC®
version 12 were used for data analysis.
CD4 counts were found highest among
- those within the age category 41-50 years,
- female,
- other ethnicities and
- participants with no formal education.
Patients experiencing adverse effects had a 2.28 fold
greater risk of poor CD4 control, while patients with comorbidities had 2.46 fold greater risk of mild viral suppression.
Adverse drug reactions, co-morbidities were found to be
significantly associated with poor immunological and virological outcomes in
HIV/AIDS patients. However, a comprehensive evaluation is needed to better
understand other confounders. This article is protected by copyright. All
rights reserved.
Via: http://ht.ly/SOykD Purchase
full article at: http://goo.gl/hE00Pf
By:
- 1School of Pharmaceutical Sciences, Universiti SainsMalaysia (USM), Malaysia.
- 2School of Pharmacy, International Medical University, Malaysia.
- 3School of Pharmacy, University of Queensland, Australia.
- 4Department of Medicine, Hospital Sungai Buloh, Selangor, Malaysia.
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