Multiple specific populations, including MSMs, IDUs, and
FPDs, are involved in HIV epidemic in China. In recent years, HIV transmission
due to heterosexual transmission also contributed greatly to HIV epidemic in
China. Very few studies have been fulfilled to characterize relationships of
HIV-1 strains prevalent in different populations. In this study, the
phylogenetic relationships of HIV-1 spreading in different populations were
investigated.
HIV-1 sero-positive patients infected through different
routes were enrolled into the study. Nested RT-PCR was used to amplify HIV gag
and pol genes followed by sequencing.
Multiple subtypes, including subtype B (52.1%), CRF01_AE
(34.4%), CRF07_BC (6.3%), subtype C (4.2%), CRF02_AG (1.0%), CRF08_BC (1.0%)
and unique recombination forms (1.0%) were identified. Phylogenetic analysis
showed that strains from MSM, IDU, and FPDs grouped into clusters separately.
However, strains identified in heterosexual transmitted population intermixed
with all of other high risk populations.
The genetic data supposed that HIV-1 was spreading out of
MSMs, IDUs, and FPDs through heterosexual transmission in Hebei, China. Urgent
prevention and behavior intervention in the population will be necessary.
Furthermore, the detailed sequence data will help the design of HIV-1 vaccines
in China.
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1State Key Laboratory of Pathogen and Biosecurity;Beijng Institute of microbiology and Epidemiology, China.
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