Human immunodeficiency virus (HIV) infection may impact
tuberculosis (TB) diagnosis, clinical presentation and treatment outcomes in
children as the signs and symptoms of both diseases overlap.
To compare the sociodemographic and clinical profiles of childhood
TB according to HIV status in Brazil.
This was a cross-sectional study of data on subjects aged
<15 years retrieved from the Brazilian National Electronic Disease Registry
(Sistema de Informação de Agravos de Notificação) database on TB to compare
TB-HIV coinfected patients and patients with TB only registered between 2007
and 2011. A hierarchical logistic regression model was applied.
Of 6091 cases analysed, 780 (12%) were TB-HIV patients,
while 5311 (87%) presented with TB only. TB-HIV patients were more likely to be
institutionalised, to present with relapsed TB and be readmitted after treatment default. They were also more likely to have unfavourable outcomes,
including default, death due to TB and death from other causes.
Our study highlights the challenges of using national
registers for research into childhood TB
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By:
- 1Laboratory of Epidemiology, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; School of Nursing, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil.
- 2Laboratory of Epidemiology, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; School of Nursing, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; Post-Graduate Programme in Infectious Diseases, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
- 3School of Nursing, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil.
- 4Faculty of Medicine<sup>, </sup> Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
- 5Department of Public Health, University of Brasilia, Brasilia DF, Brazil.
- 6Laboratory of Epidemiology, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; School of Nursing, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; Post-Graduate Programme in Infectious Diseases, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil; Post-Graduate Program in Public Health, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
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