Evaluation of Immune Response to Measles Component of MMR Vaccine in Children with HIV Infection Receiving Antiretroviral Therapy

Children with HIV (CLHIV), respond poorly to primary immunization with measles vaccine and those responding tend to lose protective titre of antibodies by 2-3 years of age. Revaccinating CLHIV after immune reconstitution with anti-retroviral therapy (ART) may result in good sero-conversion,thereby confering them protection from measles.

To study prevalence of -measles antibodies in CLHIV receiving ART before and after inmunization with MMR vaccine.

CLHIV in the age 5-18 years,receiving ART for >6 months and with CD 4 count >15% were included in this prospective study. Their serum was assayed for IgG measles antibodies by qualitative immune-enzymatic determination using ELISA. The subjects were then immunized with a single dose of MMR vaccine. A repeat venous sample was assayed for measles antibiodies 8-12 weeks after immunization.

Sixty six subjects (46 males,20 females, mean age 10.4±2.8 years )were enrolled. The mean duration of ART was 3.4±1.5 years and median CD4 count 716.5µ/L. At enrollment, 16 (24.2%) subjects tested positive, 8 (12.1%)equivocal and 42 (63.6%) negative for -measles antibodies. After 8-12 weeks of immunization, 62 (93.3%)tested positive, 1(1.5%) equivocal and 3 (4.5%) negative. There was no difference among the sero-positive and sero-negative subjects post immunization with respect to age, sex, duration of ART, nutritional status, CD4 count or WHO clinical stage. No serious adverse reaction was observed to vaccination.

MMR vaccine leads to an excellent seroconversion to measles component of vaccine in immune- reconstituted CLHIV.

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By: Seth A1, Deepa S, Dutta R, Chandra J.

• 11Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India 2Department of Microbiology, Lady Hardinge Medical College, New Delhi, India. 

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