Pain has been associated with
increased risk for mortality in some studies. We analyzed data from a cohort
study [HIV-longitudinal interrelationships of viruses and ethanol (HIV-LIVE)]
of HIV-infected persons with alcohol use disorders enrolled 2001-2003 to
explore whether reporting moderate or greater pain interference was associated
with mortality.
The main independent variable was pain that at least moderately
interfered with work based on a single question from the SF-12. Primary
analyses dichotomized at "moderately" or above. Cox proportional
hazards models assessed the association between pain interference and death
adjusting for demographics, substance use, CD4 count, HIV viral load and
co-morbidities. Although significant in unadjusted models (HR = 1.58
(95 % CI 1.03-2.41; p value = 0.04)), after adjusting for
confounders, ≥ moderate pain interference was not associated with an increased
risk of death [aHR = 1.30 (95 % CI 0.81-2.11, p
value = 0.28)].
Among HIV-infected persons with alcohol use
disorders, we did not detect a statistically significant independent
association between pain interference and risk of death after adjustment for
potential confounders.
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at:
- 1Section of General Internal Medicine, Department of Medicine, University of Washington School of Medicine and Harborview Hospital, 401 Broadway, 5th Floor, Seattle, WA, 98122, USA. tsuij@uw.edu.
- 2Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston University and Boston Medical Center, Boston, MA, USA.
- 3Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
- 4Data Coordinating Center, Boston University School of Public Health, Boston, MA, USA.
- 5Division of Infectious Diseases, University of Alabama School of Medicine, Birmingham, AL, USA.
- 6Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA.
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