Monday, October 19, 2015

Profile Analysis of Patients with HIV/AIDS Hospitalized After the Introduction of Antiretroviral Therapy

Since the introduction of highly active antiretroviral therapy (HAART) in 1996, there have been worldwide shifts in the causes of hospitalization for patients with HIV/AIDS. 

The aim of this study was to describe the characteristics of HIV/AIDS patient hospitalizations between 1997 and 2012. This cross-sectional study used a hospital database that centralizes records of admissions in 31 hospitals, both public and private, across 26 municipalities in the interior of São Paulo. 

In order to verify associations between the variables, we used the prevalence ratio (PR) and a 95% confidence interval. Among 9,797 adults and children, 10,696 admissions were registered, which was equal to 1.09 admissions per patient. 

Most (62%) of the patients were male, and the predominant age group was 21 and 50 years (63.5%). Mortality was higher among male patients from all age groups (PR= 1.42 [95% CI: 1.28-1.57]; p < 0.05). 

The main cause of hospitalization (54.5% of the total) was infectious disease, whether opportunistic or not. This was true, even in the post-HAART era. 

Furthermore, gender and age differences were noted in patient mortality rates.


Table 1 Distribution of HIV/AIDS patient hospitalizations from 1997 to 2012, arranged according to gender and age. 
Gender
Age Group (years)Male N(%)Female N(%)TotalP*
0 to 10399 (47.5)441 (52.5)840< 0.05
11 to 20147 (47.3)164 (52.7)311> 0.05
21 to 301087 (55.4)874 (45.6)1961< 0.05
31 to 402762 (67.8)1312 (32.2)4074< 0.05
41 to 501246 (68.3)578 (31.7)1824< 0.05
51 to 60327 (59.0)227 (41.0)554< 0.05
61 to 70121 (63.0)71 (37.0)192< 0.05
> 70544 (58.2)406 (41.8)934< 0.05
Total6633 (62)4063 (38)10696<0.05

*Z Test.



Table 2 Frequency distribution of children/adolescents (up to 19 years of age) and adults (> 19 years) hospitalized with HIV/AIDS between 1997 and 2012, arranged according to age group. 
Gender
Age GroupMaleFemale%
≤ 1 year97171(2.7)
> 1 & ≤ 5 yrs153139(3.0)
≥ 5 & ≤ 13 yrs211177(4.0)
> 13 & ≤ 1985118(2.1)
> 19 yrs55693077(88.3)
Total (%)6115 (62.4)3682 (37.6)9797 (100)



Table 5 Distribution of the five major causes of hospitalization (according to the ICD-10) among children and adults with HIV/AIDS hospitalized between 1997 and 2012. 
Causes of hospitalizationN%
OI*(AIDS-defining)350632.7
CAP**118711.1
Gastrointestinal infections7006.5
Urinary tract infections2372.2
TB (pulmonary & extrapulmonary)1702.0
Total580054.5
*Opportunistic infections.

**Community-acquired pneumonia.

Full article at: http://goo.gl/z6nCda

  • 1Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil, altacilio@fmrp.usp.br.
  • 2Hospital das Clínicas, FMRP, Universidade de São Paulo, Brasil.
  • 3Faculdade de Medicina de Itajubá, Brasil.  

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