Few studies have explored the trends in central precocious
puberty (CPP) in Asian populations. This study assessed the prevalence and
annual incidence of CPP among Korean children.
Using data from the Korean Health Insurance Review Agency
from 2004 to 2010, we reviewed the records of 21,351 children, including those
registered with a diagnosis of CPP for the first time and those diagnosed with
CPP who were treated with gonadotropin-releasing hormone analogs.
The prevalence of CPP was 55.9 per 100,000 girls and 1.7 per
100,000 boys, respectively. The overall incidence of CPP was 15.3 per 100,000
girls, and 0.6 per 100,000 boys. The annual incidence of CPP in girls
significantly increased from 3.3 to 50.4 per 100,000 girls; whereas in boys, it
gradually increased from 0.3 to 1.2 per 100,000 boys. The annual incidence of
CPP in girls consistently increased at all ages year by year, with greater
increases at older ages (≥6 years of age), and smaller increases in girls aged
< 6 years. In contrast, the annual incidence remained relatively constant in
boys aged < 8 years, while a small increase was observed only in boys aged 8
years. The increase of annual incidence showed significant differences
depending on age and gender (P <0.0001).
The annual incidence of CPP has substantially increased
among Korean girls over the past 7 years. Continued monitoring of CPP trends
among Korean children will be informative.
Below: The annual incidence of central precocious puberty among Korean children
Full article at: http://goo.gl/WYaoLL
By:
Shin Hye Kim, Mi-Jung Park
Department of Pediatrics,
Sanggye Paik Hospital, Inje University, College of Medicine, Seoul, Korea
Kyoung Huh
Kium Pediatric Clinic, Seoul,
Korea
Sungho Won
Department of Public Health
Science, Seoul National University, Seoul, Korea
Kuk-Wha Lee
Division of Pediatric
Endocrinology, Mattel Children's Hospital at University of California at Los
Angeles, David Geffen School of Medicine, Los Angeles, California, United
States of America
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