Setting: Tuberculosis (TB) clinic in Tijuana,
México.
Chronic airway obstruction (CAO) can be a sequella of
pulmonary tuberculosis (PTB), independently of smoking history.
To determine the prevalence of CAO in subjects recently
recorded as cured after treatment of PTB, and its impact on quality of life.
Overall, 34.3% of patients with a history of PTB had
non-reversible CAO, defined as FEV1 <70% post-bronchodilator. Subjects with
CAO had significantly more radiographic fibrocavitary sequellae on chest
X-rays, more extensive changes (1.8 ± 0.8 affected quadrants vs. 1.3 ± 0.6, P =
0.04), more residual lung cavities (1.4 ± 0.8 vs. 0.5 ± 0.7, P = 0.002), and
greater mediastinal retraction (42.4% vs. 16.7%, P = 0.026). The mean COPD
Assessment Test score for subjects with CAO was 15.1 ± 10.4. The prevalence of
irreversible CAO using the lower limit of normal criteria was higher (40%) than
that calculated with fixed ratio criteria (34.3%).
Functional abnormalities are frequently already present at
the end of treatment for PTB; patients with CAO are often symptomatic and
experience a significant impact on quality of life.
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- 1Clínica y Laboratorio de Tuberculosis, Hospital General Tijuana, Instituto de Servicios de Salud Pública, Tijuana, Mexico; Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Baja California, Mexico.
- 2Clínica y Laboratorio de Tuberculosis, Hospital General Tijuana, Instituto de Servicios de Salud Pública, Tijuana, Mexico; Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Baja California, Mexico; Sistema Nacional de Investigadores, Consejo Nacional De Ciencia y Tecnología, Mexico City, Mexico.
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