Multidrug-resistant tuberculosis (MDR-TB) has emerged as a
major clinical public health threat and challenges the national TB control
program in Malaysia. Data that elaborates on the risk factors associated with
the development of MDR-TB is highly limited in this country. This study was
aimed to determine the risk factors associated with the development of MDR-TB
patients in peninsular Malaysia.
This was a case control study; the data were collected from
medical records of all the registered MDR-TB patients at five referral TB
hospitals in peninsular Malaysia from January 2010 to April 2014. The 105 cases
were all confirmed by a positive sputum culture of Mycobacterium tuberculosis for MDR-TB and extensively drug-resistant
(XDR)-TB. As a comparison, a total of 209 non-MDR-TB cases were randomly
selected as controls.
A total of 105 MDR-TB and 209 non MDR-TB patients were
studied. The risk factors associated with MDR-TB within the multivariate
analysis were previous tuberculosis treatment, HIV infection, being an
immigrant, and high load of positive for acid-fast bacillus (AFB) smear.
The findings of this study revealed that patients who had
received previous treatment for tuberculosis, were infected with HIV, were
immigrants, and had a high burden of positive testing for AFB smear were more
likely to have MDR-TB. An enhanced understanding of the risk factors associated
with MDR-TB strains is imperative in the development of a national policy for
public health interventions.
Full article at: http://goo.gl/0CvVq2
By: Omar Sald Elmi, Habsah Hasan, Sarimah Abdullah, Mat Zuki Mat
Jeab, Zilfalil Bin Alwi, Nyi Nyi Naing
School
of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian,
Kelantan, Malaysia
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