The association between HIV viremia and non-AIDS-defining
cancers (NADCs) is not well characterized. Viremia may contribute directly or
indirectly to cancer development and may have a differential impact on various
cancer types. Our objective was to characterize patterns of HIV viremia in a
retrospective, urban, clinical cohort (N = 320) of patients diagnosed with
NADCs.
The most common NADC’s were lung (n = 60), prostate
(n = 47), oropharyngeal (n = 32), liver (n = 29), and anal cancer (n = 20) and
Hodgkin lymphoma (n = 18). In the year before cancer diagnosis, 66 % of
all patients were virally suppressed. Patients with oropharyngeal (70 %)
and prostate cancer (78 %) had a higher proportion of visits with
suppressed viral loads. Patients diagnosed with anal cancer and Hodgkin
lymphoma were infrequently virally suppressed and more frequently had viral
loads ≥5 log10 copies/ml
in the ten years prior to cancer diagnosis.
In this cohort of HIV-infected patients diagnosed with
NADCs, there were important differences in the patterns and levels of viremia
between the different NADCs in the ten years prior to cancer diagnosis.
Patients with anal cancer and Hodgkin lymphoma had the highest proportion of
high level viremia in the ten years before cancer and the lowest frequency of
viral load suppression at cancer diagnosis.
Below: Patterns of log10 HIV RNA viral load prior to cancer diagnosis for the six most common NADCs (a) and for NADCs versus ADCs (b)
Full article at: http://goo.gl/CMNEgb
By: David J. Riedel,
# Anne F. Rositch,# and Robert R. Redfield
# Anne F. Rositch,# and Robert R. Redfield
Institute of
Human Virology and Division of Infectious Diseases, University of Maryland
School of Medicine, Baltimore, MD USA
Department of
Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
USA
Institute of
Human Virology and Division of Infectious Diseases, University of Maryland
School of Medicine, Program in Oncology, University of Maryland Marlene and
Stewart Greenebaum Cancer Center, 725 W. Lombard St., N552, Baltimore, MD 21201
USA
David J. Riedel, Phone: 410-706-5665, Email: ude.dnalyramu.vhi@ledeird.
More at: https://twitter.com/hiv_insight
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