The association between bacterial vaginosis (BV)
and incident sexually transmitted infections (STIs) in a cohort of high-risk
women from Durban, South Africa was investigated in this study.
We undertook a
secondary analysis of the Methods for Improving Reproductive Health in Africa
trial that assessed effectiveness of the latex diaphragm and lubricant gel on
HIV prevention among women. During study visits, urine specimens were collected
for testing for Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas
vaginalis. The presence of BV was based on vaginal pH and wet mount test
assessments. The association between BV and the risk for incident STIs was
determined using Cox proportional hazards model. Prevalence of BV was 31% in a
cohort of 435 women tested at baseline. Among these women, BV was significantly
associated with incident Trichomonas vaginalis (14.6 per 100 PY, p = 0.03) and
Chlamydia trachomatis infections (15.8 per 100 PY, p = 0.04). BV remained a
significant predictor for Trichomonas vaginalis infections even after adjusting
for potential confounders such as age and marital status (HR: 1.60, 95% CI:
1.00, 2.57, p = 0.04).
Our study showed an association between baseline BV
infections and incident Trichomonas vaginalis and Chlamydia trachomatis
infections. Women with BV infections should be counselled on the use of condoms
and the risk of new STIs.
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- 1HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa Nathlee.abbai@mrc.ac.za.
- 2Biostatistics Unit, South African Medical Research Council, Durban, South Africa.
- 3HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
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