Marijuana Use and Psychiatric Disorders in Perinatally HIV-Exposed Youth: Does HIV Matter?

OBJECTIVE:

 To examine longitudinal reciprocal relationships between marijuana use and psychiatric disorders, and identify the role of HIV in a sample (N = 340) of youth perinatally infected with HIV (PHIV+) and youth perinatally exposed but uninfected with HIV (PHIV-) (60.6% PHIV+; 9-16 years at baseline; 51% female).  

METHODS:  

Cross-lagged structural equation modeling was used to examine longitudinal associations between changes in marijuana use and changes in any behavioral, mood, and anxiety disorders at three time points across adolescence.  

RESULTS:  

Marijuana use predicted behavioral and mood disorders in youth, regardless of HIV status. Behavioral and mood disorders predicted marijuana use for PHIV- youth; behavioral disorders predicted marijuana use for PHIV+ youth. Anxiety disorders and marijuana use were not associated for either group.  

CONCLUSIONS:  For PHIV+ and PHIV- youth, interventions that target early marijuana use may reduce later psychiatric disorders. Similarly, treatment for early behavioral disorders may prevent subsequent marijuana use.

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By:   Elkington KS1, Cruz JE2, Warne P3, Santamaria EK4, Dolezal C3, Mellins CA3.

• 1HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute, ke2143@cumc.columbia.edu.
• 2Special Needs Clinic, New York Presbyterian Hospital and Columbia University Medical Center, and.
• 3HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute.
• 4Department of Behavioral and Social Sciences, Brown University. 

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