Population-based studies comprehensively describing
incidence patterns of human papillomavirus (HPV)-related preinvasive and
invasive neoplasms prior to widespread HPV vaccination are sparse.
We calculated age-adjusted incidence rates (IRs), IR ratios
(IRRs), and annual percent changes (APC) in IRs for potentially HPV-related
tumors diagnosed in the Surveillance, Epidemiology and End Results Program
during 1978–2007.
Overall IRs for preinvasive tumors were significantly higher
than for invasive squamous cell tumors of cervix (IRR=3.42), vulva (IRR=1.87),
and vagina (IRR=1.19) and significantly lower for adenomatous cervical tumors
(IRR=0.43), and squamous cell tumors of penis (IRR=0.64), anus (males,
IRR=0.53; females, IRR=0.14), and head and neck (H&N) (males, IRR=0.01;
females, IRR=0.02). Incidence of preinvasive squamous tumors of cervix, vagina,
and penis rose rapidly over time and decreased for invasive neoplasms. The most
rapid increases occurred for preinvasive (males, APC=16.0; females, APC=7.3)
and invasive anal tumors (males, APC=3.6; females, APC=2.3). IR patterns were
generally similar among evaluable racial/ethnic groups, with the exception of
H&N invasive tumor IRs which increased exclusively among white males.
Contrary to the opposing trends of preinvasive and invasive
squamous tumors of cervix, vagina, and penis, preinvasive and invasive anal
tumor IRs increased significantly over time by gender, age, and racial/ethnic
groups.
Successful HPV vaccination programs are needed to measurably reduce
incidence of HPV-related neoplasms in the future, particularly for cancer sites
with rising incidence rates for which effective screening modalities are
limited.
Read more at: http://ht.ly/SqNfp
By: George Kurdgelashvili, MD,1,2,* Graça M. Dores, MD, MPH,1,3 Samer A. Srour, MD,1,2 Anil K. Chaturvedi, PhD,3 Mark M. Huycke, MD,1,2 and Susan S. Devesa, PhD3
2University of Oklahoma Health Sciences Center, Oklahoma City, OK
3Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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