Showing posts with label epidemiology. Show all posts
Showing posts with label epidemiology. Show all posts

Tuesday, April 5, 2016

Garbage in, Garbage Out: Data Collection, Quality Assessment and Reporting Standards for Social Media Data Use in Health Research, Infodemiology and Digital Disease Detection

Background
Social media have transformed the communications landscape. People increasingly obtain news and health information online and via social media. Social media platforms also serve as novel sources of rich observational data for health research (including infodemiology, infoveillance, and digital disease detection detection). While the number of studies using social data is growing rapidly, very few of these studies transparently outline their methods for collecting, filtering, and reporting those data. Keywords and search filters applied to social data form the lens through which researchers may observe what and how people communicate about a given topic. Without a properly focused lens, research conclusions may be biased or misleading. Standards of reporting data sources and quality are needed so that data scientists and consumers of social media research can evaluate and compare methods and findings across studies.

Objective
We aimed to develop and apply a framework of social media data collection and quality assessment and to propose a reporting standard, which researchers and reviewers may use to evaluate and compare the quality of social data across studies.

Methods
We propose a conceptual framework consisting of three major steps in collecting social media data: develop, apply, and validate search filters. This framework is based on two criteria: retrieval precision (how much of retrieved data is relevant) and retrieval recall (how much of the relevant data is retrieved). We then discuss two conditions that estimation of retrieval precision and recall rely on—accurate human coding and full data collection—and how to calculate these statistics in cases that deviate from the two ideal conditions. We then apply the framework on a real-world example using approximately 4 million tobacco-related tweets collected from the Twitter firehose.

Results
We developed and applied a search filter to retrieve e-cigarette–related tweets from the archive based on three keyword categories: devices, brands, and behavior. The search filter retrieved 82,205 e-cigarette–related tweets from the archive and was validated. Retrieval precision was calculated above 95% in all cases. Retrieval recall was 86% assuming ideal conditions (no human coding errors and full data collection), 75% when unretrieved messages could not be archived, 86% assuming no false negative errors by coders, and 93% allowing both false negative and false positive errors by human coders.

Conclusions
This paper sets forth a conceptual framework for the filtering and quality evaluation of social data that addresses several common challenges and moves toward establishing a standard of reporting social data. Researchers should clearly delineate data sources, how data were accessed and collected, and the search filter building process and how retrieval precision and recall were calculated. The proposed framework can be adapted to other public social media platforms.

Below:  The archive (a+b+c+d), retrieved tweets (a+b), and relevant tweets (a+c+e) in Twitterverse



Below:  The average limits of 95% confidence intervals for recall (vertical axis) as the sample size of unretrieved messages increases (horizontal axis), fixing the sample size of retrieved data at 3000



Full article at:   http://goo.gl/WtdPlj

By:  1Health Media Collaboratory, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL, United States
Yoonsang Kim, Health Media Collaboratory, Institute for Health Research and Policy, University of Illinois at Chicago, Westside Research Office Building, M/C 275, 1747 W Roosevelt Rd, Chicago, IL, 60608, United States, Phone: 1 312 413 7596, Fax: 1 312 996 2703




Wednesday, February 3, 2016

Epidemiology of HIV among US Air Force Military Personnel, 1996-2011

OBJECTIVE:
The objectives of this study were to describe the epidemiology of HIV in the United States Air Force (USAF) from 1996 through 2011 and to assess whether socio-demographic characteristics and service-related mobility, including military deployments, were associated with HIV infection.

METHODS:
We conducted a retrospective cohort analysis of USAF personnel who were HIV-infected during the study period January 1, 1996 through December 31, 2011 and a matched case-control study. Cases were USAF personnel newly-diagnosed with HIV during the study period. Five randomly-selected HIV-uninfected controls were matched to each case by age, length of service, sex, race, service, component, and HIV test collection date. Socio-demographic and service-related mobility factors and HIV diagnosis were assessed using conditional logistic regression.

RESULTS:
During the study period, the USAF had 541 newly diagnosed HIV-infected cases. HIV incidence rate (per 100,000 person-years) among 473 active duty members was highest in 2007 (16.78), among black/ African-American USAF members (26.60) and those aged 25 to 29 years (10.84). In unadjusted analysis restricted to personnel on active duty, 10 characteristics were identified and considered for final multivariate analysis. Of these single (adjusted odds ratio [aOR], 8.15, 95% confidence interval [CI] 5.71-11.6) or other marital status (aOR 4.60, 95% CI 2.72-7.75), communications/ intelligence (aOR 2.57, 95% CI 1.84-3.60) or healthcare (aOR 2.07, 95% CI 1.28-3.35) occupations, and having no deployment in the past 2 years before diagnosis (aOR 2.02, 95% CI 1.47-2.78) conferred higher odds of HIV infection in adjusted analysis.

CONCLUSION:
The highest risk of HIV infection in the USAF was among young unmarried deployment-naïve males, especially those in higher risk occupation groups. In an era when worldwide military operations have increased, these analyses identified potential areas where targeted HIV prevention efforts may be beneficial in reducing HIV incidence in the USAF military population.

Below:  Incidence rates of new HIV diagnoses (and 95% confidence intervals) among active duty Air Force personnel, 1996–2011



Socio-demographic factors of HIV-infected and matched HIV-uninfected United States Air Force active duty personnel, 1996–2011.
CharacteristicCases(n = 473)Controls(n = 2315)Unadjusted Odds Ratio95% Confidence IntervalP-Value
Marital status*
  Married941297Referent--
  Other461424.21(2.78–6.38)<0.0001
  Single, never married3338739.76(7.20–13.2)<0.0001
  Missing03---
Highest education attained0.0074
  Bachelors or higher59401Referent--
  Some college or less41218901.71(1.23–2.38)0.0013
  Missing224---
Occupation* *
  Communications/ Intelligence1704942.84(2.14–3.76)<0.0001
  Engineer/ Mechanic/ Repair94757Referent--
  Healthcare481702.20(1.47–3.29)0.0001
  Other1467421.57(1.16–2.14)0.0036
  Pilot/ aircrew151520.73(0.41–1.31)0.2875
Rank
  Enlisted43019821.95(1.36,2.80)0.0003
  Officer43333Referent--
Home of Record^
  Continental US3041405Referent--
  Other/ unknown763180.87(0.59,1.30)0.5055
  Missing93592---
*Other marital status included individuals who reported that they were neither married nor single on their personnel records.
**The occupation category, engineer, included non-combat engineer; ‘Other’ occupations included infantry/ combat engineer/ Special Forces/ artillery/ armor/ motor transport/ administration and other categories.^A service member’s residence at the time of entrance to the US military.

Full article at:   http://goo.gl/fdcmcx

  • 1United States Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
  • 2Preventive and Occupational Medicine Branch, National Guard Bureau, Arlington, Virginia, United States of America.
  • 3Biostatistics, The EMMES Corporation, Rockville, Maryland, United States of America.
  • 4Infectious Disease Service, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, Texas, United States of America.
  • 5Air Force Medical Support Agency, Defense Health Headquarters, Falls Church, Virginia, United States of America.
  • 6United States Military HIV Research Program, Walter Reed Army Institute of Research, Bethesda, Maryland, United States of America.
  • 7HIV Diagnostics and Reference Laboratory, United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America. 




Saturday, September 19, 2015

Incidence of Potentially HPV-Related Neoplasms in the United States, 1978–2007

Population-based studies comprehensively describing incidence patterns of human papillomavirus (HPV)-related preinvasive and invasive neoplasms prior to widespread HPV vaccination are sparse.

We calculated age-adjusted incidence rates (IRs), IR ratios (IRRs), and annual percent changes (APC) in IRs for potentially HPV-related tumors diagnosed in the Surveillance, Epidemiology and End Results Program during 1978–2007.

Overall IRs for preinvasive tumors were significantly higher than for invasive squamous cell tumors of cervix (IRR=3.42), vulva (IRR=1.87), and vagina (IRR=1.19) and significantly lower for adenomatous cervical tumors (IRR=0.43), and squamous cell tumors of penis (IRR=0.64), anus (males, IRR=0.53; females, IRR=0.14), and head and neck (H&N) (males, IRR=0.01; females, IRR=0.02). Incidence of preinvasive squamous tumors of cervix, vagina, and penis rose rapidly over time and decreased for invasive neoplasms. The most rapid increases occurred for preinvasive (males, APC=16.0; females, APC=7.3) and invasive anal tumors (males, APC=3.6; females, APC=2.3). IR patterns were generally similar among evaluable racial/ethnic groups, with the exception of H&N invasive tumor IRs which increased exclusively among white males.

Contrary to the opposing trends of preinvasive and invasive squamous tumors of cervix, vagina, and penis, preinvasive and invasive anal tumor IRs increased significantly over time by gender, age, and racial/ethnic groups. 

Successful HPV vaccination programs are needed to measurably reduce incidence of HPV-related neoplasms in the future, particularly for cancer sites with rising incidence rates for which effective screening modalities are limited.


Read more at:  http://ht.ly/SqNfp

By: George Kurdgelashvili, MD,1,2,* Graça M. Dores, MD, MPH,1,3 Samer A. Srour, MD,1,2 Anil K. Chaturvedi, PhD,3 Mark M. Huycke, MD,1,2 and Susan S. Devesa, PhD3

1Department of Veterans Affairs Medical Center, Oklahoma City, OK
2University of Oklahoma Health Sciences Center, Oklahoma City, OK
3Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD