Showing posts with label Rochester. Show all posts
Showing posts with label Rochester. Show all posts

Tuesday, March 1, 2016

Like Parent Like Child? The Role of Delayed Childrearing in Breaking the Link Between Parent's Offending and Their Children's Antisocial Behavior

This paper investigates the impact of parents' history of violent offending, their age at first birth, and the interaction of the two on their adolescent children's violent behavior. We employ intergenerational longitudinal data from the Rochester Youth Development Study to estimate parental trajectories of offending from their early adolescence through early adulthood. We show that the particular shape of the parents' propensity of offending over time can interact with their age at first birth to protect their children from delinquency. We investigate these relationships for children at 6 and 10 years of age. We find that for some groups delaying childrearing can insulate children from their parents' offending.

Below: Three Hypothetical Paths of Offending



Below:  Violence Prevalence Trajectory Groups, Waves 1 – 10



Below:  Interquartile Ranges of Age at First Birth By Trajectory Group



...The more important research question is whether among those parents who put their children at risk by having participated in delinquent behavior, are there some relatively distal behaviors that can offset the effects of parental delinquency? That is, can even those parents who are in the high delinquent trajectory groups behave in ways that serve to protect their children from problematic behavior? Specifically, the question posed was whether having children later rather than earlier would serve to offset the effects of high parental involvement in delinquency.

The results answer the question affirmatively for those 10-year-old children of parents who were in the most delinquent trajectory group, the chronic group (group 5). The age of first birth is a protective factor for all three measures of problematic behavior for our 10-year-olds. Moreover, the impact of having parents who are in the group 5 is no longer significant once the interaction between age of first birth and group 5 membership is entered into the equation. It is important to note that this was not the case for the declining group (group 4). Their main effects of group membership on problematic behaviors were reduced to insignificance for two of the three outcomes when the interaction terms were entered into the equations. However, the interaction terms measuring the protective efficacy of delaying childbirth were not statistically significant. So, there is no protective effect of delaying childbirth. Although both group 4 and group 5 were similarly high in their offending patterns initially, the trajectory for group 4 sloped down while group 5 remained relatively high. In contrast, for group 4 (but not group 5) we found some evidence of a supportive effect for the protective role of age of first birth for the 6 year olds. The only significant impact of parental delinquency on the child’s problematic behavior was for the relationship between having parents in group 4 and the Achenbach delinquency scale. The interaction between age of first birth and parental membership in group 4 was significant as well, indicating that delaying having children protects children of relatively high risk parents even at the age of 6. The differences between 6- and 10-years-olds pose interesting questions about how mediators and protective factors might operate at different ages but we leave this for future research...

Full article at:   http://goo.gl/olPNYa

  • 1School of Criminal Justice, University at Albany, Albany NY.
  • 2Department of Sociology and Criminology & Law, University of Florida, Gainesville FL.
  • 3Department of Criminology and Criminal Justice, University of Maryland, College Park MD.
  • 4Institute on Urban Health Research, Northeastern University, Boston MA. 
  •  2015;32(3):410-444.



Wednesday, October 28, 2015

Prior Oral Contraceptive Use in Ovarian Cancer Patients: Assessing Associations with Overall & Progression-Free Survival

Prior studies have described a reduced risk of developing ovarian cancer with the use of oral contraceptives. In this context, we decided to examine if oral contraceptive use prior to a diagnosis of ovarian cancer is associated with better overall and progression-free survival.

This retrospective cohort study included ovarian cancer patients who were seen at the Mayo Clinic in Rochester, Minnesota from 2000 through 2013. Patients completed a risk factor questionnaire about previous oral contraceptive use, and clinical data were extracted from the electronic medical record.

A total of 1398 ovarian cancer patients responded to questions on oral contraceptive use; 571 reported no prior use with all others having responded affirmatively to oral contraceptive use. Univariate analyses found that oral contraceptive use (for example, ever versus never) was associated with better overall survival and better progression-free survival. In multivariate analyses, contraceptive use continued to yield a favorable, statistically significant association with progression-free survival, but such was not the case with overall survival.

This study suggests that previous oral contraceptive use is associated with improved progression-free survival in patients diagnosed with ovarian cancer.

Below:  Overall Survival Based on Ever- (solid line) and Never-Users (dashed line) of Oral Contraceptives. In univariate analyses ever-users of oral contraceptives (n = 793) manifested a longer overall survival compared to never-users (dashed line) (n = 551) (HR = 0.73 (95 % CI: 0.62, 0.86); p = 0.0002 (accounting for left truncation). Within the cohort were a total of 562 deaths. Similar statistically significant findings were seen in univariate analyses when patients were dichotomized on the basis of duration of oral contraceptive use



Below:  Progression-Free Survival Based on Ever- (solid line) and Never-Users (dashed line) of Oral Contraceptives. In univariate analyses ever-users of oral contraceptives (n = 700) manifested a longer progression-free survival compared to never-users (dashed line) (n = 489) (HR = 0.71 (95 % CI: 0.61, 0.83); p < 0.0001 (accounting for left truncation). Within the cohort were a total of 656 events of cancer progression. Similar statistically significant findings were seen in univariate analyses when patients were dichotomized on the basis of duration of oral contraceptive use



Full article at: http://goo.gl/UiTtmI

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA
Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL USA
Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS USA
Aminah Jatoi, Email: ude.oyam@hanima.iotaj.