Showing posts with label vaginal sex. Show all posts
Showing posts with label vaginal sex. Show all posts

Tuesday, May 31, 2016

Improving Adherence to Post-Cervical Biopsy Sexual Abstinence in Kenyan Female Sex Workers

PROBLEM:
Cervical biopsies offer a unique opportunity for studying local immune response. To investigate hormonally induced immune fluctuations in cervical tissues of Kenyan female sex workers, we improved biopsy sampling protocol safety. Here, we report on steps taken to minimize exposure to HIV following two cervical biopsies.

METHODS OF STUDY:
Women were asked to abstain from vaginal intercourse to limit HIV exposure during wound healing with financial compensation. A comprehension tool for informed consent, on-site detection of prostate-specific antigens indicating unprotected intercourse within 48 hr, and bi-weekly text message reminders were implemented.

RESULTS:
The implemented methods improved compliance with post-procedure abstinence by two times (P = 0.013). Fourteen days following a cervical biopsy, no sign of genital inflammation or change in HIV T-cell target proportion were observed.

CONCLUSIONS:
This study provides new tools for limiting HIV exposure in studies requiring biopsy sampling among women at risk of acquiring HIV.

Below:  Schematic representation of the study visits



Below:  PSA-semiquant cassette test serial dilutions to indicate PSA concentrations



Below:  Proportion of cervical HIV T-cell targets in HIV-uninfected and HIV-infected FSWs before and after biopsy sampling



Full article at:   http://goo.gl/tX6M5j

By: Lajoie J1,2,3Boily-Larouche G1Doering K1Cheruiyot J4Oyugi J1,3,4Broliden K5Kimani J1,3,4Fowke KR1,2,3.
  • 1Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
  • 2Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  • 3Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
  • 4Kenya AIDS Control Program, Nairobi, Kenya.
  • 5Department of Medicine Solna, Center for Molecular Medicine, Clinic of Infectious Diseases, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
  •  2016 May 24. doi: 10.1111/aji.12520. 



Wednesday, May 4, 2016

Patterns of Sexual Experience among Urban Latino & African American 9th Grade Students

This analysis assessed patterns of sexual experience, the order in which behaviors were initiated, and associated factors, among Latino and African American ninth grade students (average age 15.2) who self-administered audio-computer-assisted surveys on netbooks in classes at 10 Los Angeles–area public high schools. 

Lifetime experiences with vaginal and oral sex were most common (19% and 16%, respectively); fewer reported anal sex (6%). Of the 23% reporting any sex, 91% fell into four categories: 36% reporting both oral and vaginal sex; 23% vaginal only; 18% all three; and 13% oral only. Most sexually experienced students (88%) initiated with vaginal or oral sex (46% vaginal, 33% oral, 9% both same day). 

No dominant pathway of sexual onset emerged for those reporting all three types of sex. We found no evidence that oral or anal sex substituted for or delayed vaginal sex. Males, those with a current partner, and those reporting multiple partners were more likely than others to report all three sexual behaviors versus vaginal only (odds ratios [ORs] 2.0, 1.5, 3.0; p = .02, .06, < .01, respectively). 

Although vaginal intercourse dominated their early sexual behavior, one-fifth of sexually experienced students reported anal intercourse, highlighting the need for specific prevention messages surrounding this higher-risk behavior.

Purchase full article at:   http://goo.gl/UM5lNq
   
a Department of Mathematics and Statistics, California State University, Chico
b Los Angeles County Department of Public Health, Division of HIV and STD Programs; Institute for Health Promotion and Disease Prevention, University of Southern California
c Institute for Health Promotion and Disease Prevention, University of Southern California
d Los Angeles County Department of Public Health, Division of HIV and STD Programs
e Department of Biostatistics, Fielding School of Public Health, University of California at Los Angeles 




Thursday, March 17, 2016

Race Is Associated with Sexual Behaviors and Modifies the Effect of Age on Human Papillomavirus Serostatus among Perimenopausal Women

BACKGROUND:
Human papillomavirus (HPV) causes oropharyngeal and cervical cancers. Oropharyngeal cancer primarily affects whites, but cervical cancer is more common among blacks. Reasons for this distinct epidemiology are unclear.

METHODS:
Serum was collected from women aged 35 to 60 years in the HPV in Perimenopause cohort and evaluated for antibodies to 8 HPV types. Demographic and behavioral data were collected by telephone questionnaire. Associations between sexual behaviors, race, age, HPV serostatus, and strength of serologic response to HPV were evaluated.

RESULTS:
There were 781 women in this analysis, including 620 white (79%) and 161 (21%) black women. Whites were less likely to report 5+ vaginal sex partners (prevalence ratio [PR], 0.86; 95% confidence interval [CI], 0.77-0.97), but more likely to report 5+ oral sex partners (PR, 2.38; 95% CI, 1.62-3.49) compared with blacks. Seropositivity to most individual HPV types and at least 3 types was significantly lower in whites than in blacks (PR, 0.62; 95% CI, 0.47-0.80). Human papillomavirus seropositivity was independently associated with younger age among blacks, but with sexual exposures among whites. Furthermore, strength of serologic response to most HPV types significantly decreased with older age among blacks, but not among whites.

CONCLUSIONS:
Racial differences in immune markers of HPV exposure and the epidemiology of HPV-related cancers may be linked to differences in patterns of sexual behaviors.

Purchase full article at:   http://goo.gl/PdOzzI

  • 1From the *Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; †Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Departments of ‡Gynecology and Obstetrics and §Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; and ¶Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM.
  •  2016 Apr;43(4):231-7. doi: 10.1097/OLQ.0000000000000426. 



Tuesday, March 15, 2016

Dual Epidemics of Drug Use and Syphilis among Chinese Female Sex Workers: Results of Eight Consecutive Cross-Sectional Surveys from 2006 to 2013 in Qingdao, China

Eight consecutive annual cross-sectional surveys were conducted to examine the trend of the prevalence of HIV, syphilis, drug use and their correlates among female sex workers (FSWs) in Qingdao, China. 

Among sampled FSWs over the 8 years, a higher proportion of older, married or cohabited, higher education levels and more on-call FSWs were observed in recent years. The syphilis prevalence increased significantly from 1.0 % in 2006 to 13.5 % in 2013, with illicit drug use rate ranging from 21.8 % in 2007 to 55.5 % in 2010. 

Multivariate logistic regression analyses showed that drug use, syphilis and unprotected vaginal sex predicted each other. The dual epidemics of illicit drug use and syphilis among FSWs underscore the urgency to implement a tailored intervention to curb the dual epidemics while also preventing an HIV epidemic in the context of diversified commercial sex dynamic.

Purchase full article at:   http://goo.gl/a4GdLA

By:  Liao M1Su S1Yan K1Zhu X1Huang P1Li J1Jiang Z2Zhang X2Zhang N3Tao X1Kang D4Zhao J5.
  • 1Institution for AIDS/STD Control and Prevention & Shandong Key Laboratory for Epidemic Disease Control and Prevention, Shandong Center for Disease Control and Prevention, 16992 Jingshi Road, Jinan, 250014, Shandong Province, People's Republic of China.
  • 2Qingdao Center for Disease Control and Prevention, Qingdao, 266033, Shandong Province, People's Republic of China.
  • 3Health Counseling Center, Qingdao, 266033, Shandong Province, People's Republic of China.
  • 4Institution for AIDS/STD Control and Prevention & Shandong Key Laboratory for Epidemic Disease Control and Prevention, Shandong Center for Disease Control and Prevention, 16992 Jingshi Road, Jinan, 250014, Shandong Province, People's Republic of China. dmkang66@163.com.
  • 5Technical Advice and Partnerships Department, The Global Fund to Fight AIDS, Tuberculosis and Malaria, Chemin de Blandonnet 8, Vernier, 1214, Geneva, Switzerland. jinkouzhao@hotmail.com. 
  •  2016 Mar;20(3):655-66. doi: 10.1007/s10461-015-1229-1.



Friday, March 4, 2016

Verbal Sexual Coercion Experiences, Sexual Risk, and Substance Use in Women

Research has linked sexual assault, substance use, and sexually transmitted infection (STI) risk in women. Sexual assault by means of verbal sexual coercion (VSC) is more common than sexual assault by means of physical tactics, but VSC is rarely assessed independently. In addition, past work has established global connections among substance use, sexual assault history, and STI risk; however, assessing substance use during sexual behavior is less common. This study examined the relations among VSC, STI risk behavior, and substance use and attitudes. We hypothesized that women with larger numbers of VSC experiences would report more frequent sexual risk behaviors and substance use and attitudes. Participants with larger numbers of VSC experiences reported larger numbers of anal sex partners, more frequent penile–vaginal sex and sexual activity after substance use, and stronger sex-related alcohol expectancies. These findings suggest that VSC is associated with higher levels of STI risk in women.

The findings that larger numbers of VSC events are associated with higher numbers of lifetime vaginal and anal sexual partners are consistent with past research (; ), and suggest that women with a history of VSC are at higher risk of contracting STIs than women with no VSC history. Results from this research extend previous knowledge by adding a contextual examination of substance use during sexual behaviors, such that women with more VSC experiences reported more frequent sexual activity after marijuana use (Hypothesis 8) and after combined alcohol and marijuana use (Hypothesis 9). Marijuana use is related to sexual risk behaviors (; ; ), as is alcohol use (; ; ; ). Studies have yet to examine how combined alcohol and marijuana use affects sexual risk. It is possible that alcohol and marijuana potentiate each other, such that the combination exponentially increases both STI and sexual risk, perhaps through impaired cognitive function and capacity for risk perception. However, we only assessed for sexual behavior and did not assess if event-level STI risk or sexual assault risk increased when individuals used substances during sexual behavior. Future work should assess this possibility.

The findings reported here cannot speak to why women with a history of VSC reported higher concomitant marijuana use and sexual activity. Thus, future research should evaluate women's motives and expectancies () for using marijuana prior to sexual activity to evaluate possible differences based on VSC history. Women with larger numbers of VSC experiences reported stronger sex-related alcohol expectancies, which is also consistent with past research (Hypothesis 4; ). Alcohol expectancy theory posits that individuals are more likely to behave in a manner consistent with their view of how alcohol affects them (). Therefore, if an individual has stronger sexual risk alcohol expectancies, he or she might engage in riskier sexual behavior while intoxicated than when sober…

Full article at:   http://goo.gl/PcPC5A

Amanda k. Gilmore, Department of Psychology, University of Washington, Seattle, Washington, USA;
Address correspondence to Amanda K. Gilmore, Department of Psychology, University of Washington, Box 351525, Seattle, WA 98195. ude.wu@gkadnama





Tuesday, February 23, 2016

Gender Differences in HIV Sexual Risk Behaviors among Clients of Substance Use Disorder Treatment Programs in the U.S.

This study examined differences in sexual risk behaviors by gender and over time among 1281 patients (777 males and 504 females) from 12 community-based substance use disorder treatment programs throughout the United States participating in CTN-0032, a randomized control trial conducted within the National Drug Abuse Treatment Clinical Trials Network. Zero-inflated negative binomial and negative binomial models were used in the statistical analysis. 

Results indicated significant reductions in most types of sexual risk behaviors among substance users regardless of the intervention arms. There were also significant gender differences in sexual risk behaviors. 
  • Men (compared with women) reported more condomless sex acts with their non-primary partners and condomless anal sex acts, but 
    • fewer condomless sex partners, 
    • condomless vaginal sex acts, 
    • and condomless sex acts within 2 hours of using drugs or alcohol. 
Gender-specific intervention approaches are called for in substance use disorder treatment.

Purchase full article at:   http://goo.gl/ymhjTJ

  • 1Department of Public Health Sciences, University of Miami Miller School of Medicine, Clinical Research Building, Room 1066, 1120 N.W. 14th St., Miami, FL, 33136, USA. panyue@med.miami.edu.
  • 2Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • 3Department of Biostatistics, Robert Stempel College of Public Health & Social Work at Florida International University, Miami, FL, USA.
  • 4Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA.
  • 5Department of Public Health Sciences, University of Miami Miller School of Medicine, Clinical Research Building, Room 1066, 1120 N.W. 14th St., Miami, FL, 33136, USA.
  • 6Aspire Health Partners, Orlando, FL, USA. 
  •  2016 Feb 18.



Friday, February 5, 2016

A Comparison of Actual and Perceived Sexual Risk among Older Adults

Sexual risk among older adults (OAs) is prevalent, though little is known about the accuracy of sexual risk perceptions. Thus, the aim was to determine the accuracy of sexual risk perceptions among OAs by examining concordance between self-reported sexual risk behaviors and perceived risk. Data on OAs aged 50 to 92 were collected via Amazon.com's Mechanical Turk. 

Frequency of sexual risk behaviors (past six months) were reported along with perceived risk, namely, sexually transmitted infection (STI) susceptibility. Accuracy categories (accurate, underestimated, overestimated) were established based on dis/concordance between risk levels (low, moderate, high) and perceived risk (not susceptible, somewhat susceptible, very susceptible). Approximately half of the sample reported engaging in vaginal (49%) and/or oral sex (43%) without a condom in the past six months. However, approximately two-thirds of the sample indicated they were "not susceptible" to STIs. 

No relationship was found between risk behaviors and risk perceptions, and approximately half (48.1%) of OAs in the sample underestimated their risk. Accuracy was found to decrease as sexual risk level increased, with 93.1% of high-risk OAs underestimating their risk. Several sexual risk behaviors are prevalent among OAs, particularly men. However, perception of risk is often inaccurate and warrants attention.

Purchase full article at:   http://goo.gl/ExocJU

  • 1 Center on Aging , Kansas State University.
  • 2 Department of Psychology , Radford University.
  • 3 Department of Psychology , The College of New Jersey. 



Saturday, January 9, 2016

Predictors of Injection Cessation and Relapse among Female Sex Workers who Inject Drugs in Two Mexican-US Border Cities

We know little about predictors of injection drug cessation and relapse among female sex workers who inject drugs (FSW-PWID) at the US-Mexico border. 

Among HIV-negative FSW-PWID taking part in a behavioral intervention study in Tijuana and Ciudad Juárez, Cox regression was used to identify predictors of time to first cessation of injection, which was defined as reporting not having injected drugs for a period of 4 months or longer, and among that subset, we examined predictors of time to injection relapse. 

Among 440 women, 84 (19 %) reported ceasing injection during follow-up (median time to cessation = 9.3 months); of these, 30 (35 %) reported relapse to injection (median time to relapse = 3.5 months). The rate of injection cessation was lower for women reporting trading sex prior to age 18, ever being sexually abused, and a higher number of vaginal sex acts with casual clients. The rate of cessation was higher for women who spent more hours on the streets on a typical day and who lived in Tijuana vs. Ciudad Juárez. The rate of relapse was higher among women reporting regular drug use with clients and those scoring higher on a risk injection index. The rate of relapse was lower for FSW-PWID with higher than average incomes. 

These findings have important implications for the scale-up of methadone maintenance treatment programs (MMTPs) in Mexico and indicate a need for gender-specific programs that address sexual abuse experiences and economic vulnerabilities faced by FSW-PWID.

Purchase full article at:   http://goo.gl/EbvN4c

  • 1Division of Global Public Health, Department of Medicine, University of California San Diego, 9500 Gilman Drive 0507, La Jolla, CA, 92093-0507, USA. bswest@ucsd.edu.
  • 2Division of Global Public Health, Department of Medicine, University of California San Diego, 9500 Gilman Drive 0507, La Jolla, CA, 92093-0507, USA.
  • 3Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
  • 4Departamento de Ciencias Médicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, Mexico. 






Friday, January 1, 2016

Vaginal and Oral Sex Initiation Timing: A Focus on Gender and Race/Ethnicity

OBJECTIVES:
Most previous studies on sexual initiation timing have examined its effects on a variety of subsequent outcomes without first examining the correlates and predictors of these timing categories. Studies that do exist often do not utilize samples through young adulthood, leading to a misclassified set of sexual timing categories. In addition, the literature does not adequately address the issues of oral sex timing. Therefore, the objectives of this study were 1) to explore age-cutoffs that mark the "normative" and "non-normative" entry into vaginal and oral sex among young women and men in the U.S., creating sexual four sexual initiation timing categories - "early," "normative," "late," and "inexperienced," and; 2) to examine the association between race/ethnicity and sexual initiation timing by gender.

METHODS:
The National Longitudinal Study of Adolescent to Adult Health (Add Health) was used in both descriptive and multivariate contexts to determine the net association of gender and race/ethnicity with vaginal and oral sex initiation timing.

RESULTS:
Age-cutoffs for vaginal sex timing were similar for women and men, yet differed by gender for oral sex timing. Women were more likely than men to initiate vaginal sex (20% vs. 18%) and oral sex (19% vs. 16%) at an early age and less likely than men to initiate these behaviors at a late age (18% vs. 19% for vaginal sex, and 15% vs. 16% for oral sex). Although most respondents initiated these two behaviors by young adulthood, a considerable proportion remained inexperienced, with men more likely than women to report inexperience with vaginal sex (7% vs. 5%), and women more likely than men to report abstaining from oral sex (8% vs. 6%). Race/ethnic differences in sexual initiation timing remained robust in the face of controls for both women and men.

CONCLUSIONS:
Understanding the timing at which adolescents and young adults transition to first vaginal and first oral sex is critical for sex education curriculum and policy makers.

Below:  Weighted Percentages of Sexual Initiation Timing by Gender and Race/Ethnicity



Full article at:   http://goo.gl/1P7DdJ

Author Contact: Giuseppina Valle, Ph.D, Postdoctoral Fellow, Population Research Center, The University of Texas at Austin, 305 E. 23rd Street, Stop G1800, Austin, TX 78712-1699, Phone: 585-506-6557, Email: ude.saxetu.crp@ellavg



Saturday, December 26, 2015

The Impact of Criminalization of HIV Non-Disclosure on the Healthcare Engagement of Women Living with HIV in Canada

Introduction
In 2012, the Supreme Court of Canada ruled that people living with HIV (PLWH) must disclose their HIV status to sexual partners prior to sexual activity that poses a “realistic possibility” of HIV transmission for consent to sex to be valid. The Supreme Court deemed that the duty to disclose could be averted if a person living with HIV both uses a condom and has a low plasma HIV-1 RNA viral load during vaginal sex. This is one of the strictest legal standards criminalizing HIV non-disclosure worldwide and has resulted in a high rate of prosecutions of PLWH in Canada. Public health advocates argue that the overly broad use of the criminal law against PLWH undermines efforts to engage individuals in healthcare and complicates gendered barriers to linkage and retention in care experienced by women living with HIV (WLWH).

Methods
We conducted a comprehensive review of peer-reviewed and non-peer-reviewed evidence published between 1998 and 2015 evaluating the impact of the criminalization of HIV non-disclosure on healthcare engagement of WLWH in Canada across key stages of the cascade of HIV care, specifically: HIV testing and diagnosis, linkage and retention in care, and adherence to antiretroviral therapy. Where available, evidence pertaining specifically to women was examined. Where these data were lacking, evidence relating to all PLWH in Canada or other international jurisdictions were included.

Results and discussion
Evidence suggests that criminalization of HIV non-disclosure may create barriers to engagement and retention within the cascade of HIV care for PLWH in Canada, discouraging access to HIV testing for some people due to fears of legal implications following a positive diagnosis, and compromising linkage and retention in healthcare through concerns of exposure of confidential medical information. There is a lack of published empirical evidence focused specifically on women, which is a concern given the growing population of WLWH in Canada, among whom marginalized and vulnerable women are overrepresented.

Conclusions
The threat of HIV non-disclosure prosecution combined with a heightened perception of surveillance may alter the environment within which women engage with healthcare services. Fully exploring the extent to which HIV criminalization represents a barrier to the healthcare engagement of WLWH is a public health priority.

Below:  Summary of the historical and current case law for HIV non-disclosure, reflecting two key rulings by the Supreme Court of Canada



Below:  Gardner's cascade of HIV care. Figure illustrating key steps in the cascade of HIV care, from primary HIV infection to viral suppression 


Full article at:   http://goo.gl/p69YEx

1Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada
2BC Centre for Excellence in HIV/AIDS, St Paul's Hospital, Vancouver, BC, Canada
3Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
4School of Social Work, McMaster University, Hamilton, ON, Canada
5British Columbia Civil Liberties Association, Vancouver, BC, Canada
§Corresponding author: Angela Kaida, Faculty of Health Sciences, Simon Fraser University, BLU 10522, 8888 University Drive, Burnaby, BC, Canada V5A1S6. Tel: +1 778 782 9068. Fax: +1 778 782 5927. (Email: ac.ufs@adiak_alegna)