Tuesday, August 25, 2015

Geographic Distribution of HCV Genotypes in Libya & Analysis of Risk Factors Involved in their Transmission

Below:  Geographical distribution of HCV genotypes according to the Libyan regions (color-coded). Data indicate percentage of patients infected by genotype in each region.


Below:  The distribution of HCV genotypes among different age groups of Libyan populations



Below:  The influence of gender on the distribution of HCV genotypes among Libyans



Below:  Distribution of hepatitis C genotype during the period of 2000–2006


A total of 20 discrete genotypes and subtypes were identified among the Libyan population ranging from 11.5 to 0.3 % cross the country. Genotype 1 was the most frequent among all regions (19.7–40.5 %), reaching the highest value in Tripoli region, followed by genotype 4 which was more prevalent in the South (49.3 %) and West (40.0 %) regions. Genotype 3, was higher in Tripoli (21.3 %) and East (15.9 %) regions while genotype 2, common in North (23.6 %) and South (22.5 %) regions. However, we found evidence that there is a changing relative prevalence of HCV genotypes in relation to age, gender and the mode of transmission which is reflected in the predominance of certain genotypes among Libyan population.

Different HCV genotypes were isolated form Libyan population including newly emerged ones. The prevalence of the genotypes varied by geographic region and influenced by demographic and risk factors. Knowing the frequency and distribution of the genotypes would provide key information on understanding the spread of HCV in Libya and this could be greatly reflected on national plans and future strategies for infection prevention.

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