Below: Progressive change in median CD4 Counts over the follow up period in four selected health facilities of Kembata and Hadiya zones of SNNPR, Ethiopia [2007–2011]
Below: Cumulative survivals for real (death) and worst case (lost) assumptions of patients during follow up periods in four selected health facilities of Kembata and Hadiya zones of SNNPR, Ethiopia, 2007–2011
Below: Cumulative Hazard function for real and worst case assumptions during follow up periods in four selected health facilities of Kembata and Hadiya zones of SNNPR, Ethiopia, 2007–2011
Below: Overall model fit of the Cox regression using the Cox-Snell residuals
Median age of patients was 32.4 years with Inter Quartile Range (IQR) [15, 65]. The female to male ratio of the study participants’ was 1.4:1. Median CD4 count significantly increased during the last four consecutive years of follow up. A total of 92 (12.6 %) patients died, 106(14.5 %) were lost to follow-up, and 109(15 %) were transferred out. Sixty three (68 %) deaths occurred in the first 6 months of treatment. The median survival time was 25 months with IQR [9, 43]. After adjustment for confounders, WHO clinical stage IV [HR 2.42; 95 % CI, 1.19, 5.86], baseline CD4 lymphocyte counts of 201 cell/mm 3 and 350 cell/mm 3 [HR 0.20; 95 % CI; 0.09−0.43], poor regimen adherence [HR 2.70 95 % CI: 1.4096, 5.20], baseline hemoglobin level of 10gm/dl and above [HR 0.23; 95 % CI: 0.14, 0.37] and baseline functional status of bedridden [HR 3.40; 95 % CI: 1.61, 7.21] were associated with five year survival of HIV patients on ART.
All people living with HIV/AIDS should initiate ART as early as possible. Initiation of ART at the early stages of the disease, before deterioration of the functional status of the patients and before the reduction of CD4 counts and hemoglobin levels with an intensified health education on adherence to ART regimen is recommended.
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