Friday, September 11, 2015

Measuring Outcome in the Treatment of Cocaine Dependence

Below:  Patterns of Cocaine Use from Baseline to Month 18 Among Patients Identified as “Continued Users” (N=215) During Months 1 to 4 of Active Treatment. Note: The proportion of patients who used cocaine at each assessment is evaluated on a compositive cocaine use measure that combined information from self-report, urines, and the Addiction Severity Index cocaine use item.



Below:  Patterns of Cocaine Use from Baseline to Month 18 Among Patients Identified as “Slower Improvers” (N=90) During Months 1 to 4 of Active Treatment



Below: Patterns of Cocaine Use from Baseline to Month 18 Among Patients Identified as “Immediate Abstainers” (N=125) During Months 1 to 4 of Active Treatment


Measures of during-treatment reduction in use were moderately correlated with drug and cocaine use measures 12 months, but showed non-significant or small correlations with measures of functioning at 12 months. Highest correlations were evident for abstinence measures (maximum consecutive days abstinence and completely abstinent) during treatment in relation to sustained (3 month) abstinence at 12 months. Latent class analysis of patterns of change over time revealed that most patients initially (months 1 to 4 of treatment) either became abstinent immediately or continued to use every month. Over the couse of follow-up, patients either maintained abstinence or used regularly – intermittent use was less common.

There were generally small associations between various measures of cocaine use and longer-term clinical benefits, other than abstinence was associated with continued abstinence. No one method of measuring outcome of treatment of cocaine dependence appears superior to others.

Read more at:  http://ht.ly/S4Nt6

By: Paul Crits-Christoph,a Robert Gallop,b Mary Beth Connolly Gibbons,a Jaclyn S. Sadicario,a and George Woodya


aDepartment of Psychiatry, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
bApplied Statistics Program, Department of Mathematics, West Chester University, 25 University Avenue, West Chester, PA 19383, USA

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