Treatment of HIV+ Subjects with Buttock Lipoatrophy Using Stabilized Hyaluronic Acid Gel

Below:   T2-weighted fast spin echo magnetic resonance imaging with fat saturation, showing a gradual decrease in volume of the injected gel (with no local displacement of gel). At 1 month, the estimated mean volume of gel was 133% (n = 5; range: 120–147%) of the mean injected volume. At 6, 9, and 12 months, the estimated mean volume of remaining gel had decreased to 81% (n = 8; range: 48–119%), 47% (n = 6; range: 15–104%), and 31% (n = 7; range: 9–51%), respectively. Interindividual variance was high.

Below:  A, Mean change from baseline in pain after 15 minutes of sitting (measured using a VAS), intention to treat (ITT) population (n = 10). The lowest mean pain score was noted 3 months after treatment (mean change from baseline: −40 mm [95% CI, −47.7 to −32.8). At 6 months, mean change from baseline was −28 mm (95% CI, −44.0 to −12.2). At this time point, 9 subjects (90%) experienced decreased pain. Significant difference from baseline: *P < 0.05, **P < 0.01, ***P < 0.001. VAS, visual analogue scale. B, Mean change from baseline in time to when subjects could no longer stay in the sitting position, ITT population (n = 10). Six months after treatment, the mean time that subjects could remain seated was increased with 35 minutes (95% CI, 31.0–39.4). The longest mean time that subjects could remain seated was noted 12 months after the treatment. By then, all subjects for whom data were recorded (n = 5) were able to remain seated for more than 60 minutes (mean change from baseline: 37 minutes [95% CI, 31.2–43.7]). Significant difference from baseline: ***P < 0.001.

This prospective study explored effectiveness and safety of Macrolane VRF30 for treatment of buttock lipoatrophy in HIV-infected subjects. Ten subjects who were unable to sit for more than 30 minutes because of pain were injected with a mean of 276 mL and followed for 18 months. The pain score was reduced, and the time that subjects could sit was increased at least up to 9 months post treatment. There was no local displacement of gel. Five mild adverse events occurred; all related to the injection procedure. This pilot study indicates that Macrolane treatment of buttock lipoatrophy is a promising, well-tolerated method that reduces pain at sitting and improves buttock appearance.

Read more at:  http://ht.ly/RKLSj HT https://twitter.com/NCBI