Human Papilloma Virus (HPV) infection is the most common
sexually transmitted viral infection worldwide. HPV is highly prevalent in
sexually active men who have sex with men (MSM) and has been associated with
anal cancer, penile cancer, and oropharyngeal cancer.
From March to September 2011, we conducted a cross-sectional
study of HPV prevalence among MSM above age 18 years. Participants were
recruited using respondent driven sampling at Clinica Cayetano Heredia. All
participants provided anal, genital, and oral samples for HPV DNA testing, and
blood for HIV and HPV antibody testing.
A total of 200 MSM were recruited in the study. The mean age
was 34 years (range 18–59 years, SD = 9.4) and101 participants were HIV
negative (99 HIV positive). HPV 6/11/16/18 or quadrivalent HPV vaccine (HPV4)
genotype seroprevalence among HIV negative and positive MSM was 64.3%
(55%-75.9%) and 93.8% (87.6%-99.2%) respectively (p<0.001). HIV positivity
was associated with a higher prevalence of HPV4 and HPV 16/18 DNA at external
genital sites and the anal canal. HPV4 DNA prevalence at external genital sites
among HIV negative and positive MSM was 14.9% and 28.7% (p = 0.02)
respectively, at anal canal was 50.9% and 79.0% (p = 0.001), and at the oral
cavity was 9.9% and 8.5% (p = 0.6).
HPV4 seroprevalence was high in our study among both HIV
positives and negatives, with HPV DNA prevalence much lower, and the anal canal
being the anatomical site with the highest HPV DNA prevalence. HPV prevention
interventions are needed among MSM at high-risk for HIV infection.
Below: Representation of the seeds and their referred participants
Full article at:
By:
Magaly M. Blas, Luis Menacho, Isaac E. Alva, Cesar Carcamo
Epidemiology, STD and HIV Unit, School of Public Health and
Administration, Universidad Peruana Cayetano Heredia, Lima, Peru
Brandon Brown
Center for Healthy Communities, UCR School of Medicine,
Riverside, California, United States of America
Alfonso Silva-Santisteban
Unit of Health, Sexuality and Human Development, School of
Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima,
Peru
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