The results showed that both parents had occult infections while the child had an overt infection. Twelve, eleven and nine clones, from the father, mother and son, respectively, were sequenced. Serotypes adrq+, ayw1, ayw and ayr were found in the father and ayw1, adw2 and adwq+ in the mother; adrq+ was the only serotype in son. Genotype B, subgenotype C2 and a recombinant were identified in the father and genotype B, subgenotype C5 and three recombinants were found in the mother. Subgenotype C2 was the only genotype identified in the child. A phylogenetic tree showed that all of the child’s sequences and most of the father’s sequences clustered together. However, none of mother’s sequences clustered with those of the child. The surface gene from the child and his father had the same amino acid substitution pattern (T118K, T123N and G145A).
We concluded that the father was the source of the son’s HBV infection, suggesting that occult HBV infection may be transmitted through close contact and manifest as an overt infection.
Full article at: http://goo.gl/O0qKuC
By:
Li-Ping Hu, Qin-Yan Chen, Xue-Yan Wang, Hai Li, Chao Tan,
Qing-Li Yang, Kai-Wen Li, Zhong-Liao Fang
Guangxi Zhuang Autonomous Region Center for Disease
Prevention and Control, Guangxi Key Laboratory for the Prevention and Control
of Viral Hepatitis, Nanning, Guangxi 530028, China
Li-Ping Hu, Kai-Wen Li
School of Preclinical Medicine, Guangxi Medical University,
22 ShuangYong Road, Nanning, Guangxi 530021, China
De-Ping Liu
Chong Zuo Center for Disease Prevention and Control, Lijiang
road, Chong Zuo, Guangxi 532200, China
Tim J. Harrison
Division of Medicine, UCL Medical School, London, United
Kingdom
Xiang He
Guangdong Provincial Institute of Public Health, Guangdong
Provincial Center for Disease Control and Prevention, Guangzhou 511430, China
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