Hepatitis C is the second leading viral infectious disease
worldwide. In Iran, hepatitis C is the most important and prevalent reason for
chronic hepatitis and liver cirrhosis in the multi transfused population.
This study was conducted to determine seroprevalence and
burden of hepatitis C in Chaharmahal and Bakhtiari province and to plan for
controlling it.
For this analytical, population-based study, 3000 samples
were older than 15 years old and were enrolled from urban and rural areas of
Chaharmahal and Bakhtiari province, southwest Iran per cluster sampling.
Written informed consent was obtained from the participants and the demographic
data, transmission route and risk factors were collected after blood sample
taking. Hepatitis C virus antibody (HCV Ab) and western blotting were
consecutively run.
Data analysis was done by SPSS 19 using descriptive
statistics, and chi-square test, Fisher's exact test, and logistic regression
Ap value of 0.05 was considered as the level of significance.
The prevalence of HCV Ab was obtained 1.4% (95% CI, 0.95-1.7)
and that of positive hepatitis C by western blotting 0.9% (95% CI, 0.65-1.3).
The prevalence in men (1.2%) was obtained two times higher than women. The
highest prevalence was obtained in 35 to 44-year-old population (2%). The
prevalence was higher in married individuals and less in higher educated.
History of hospital stay, first degree relatives infected with HCV, jaundice,
history of blood transfusion, tattoo, outpatient surgery, imprisonment, contact
with the infected, intravenous (IV) drug abuse, and smoking had significant
association with disease prevalence (p<0.05). The highest odds ratio was
obtained for history of IV drug abuse (OR=38.2, 95% CI, 14.06-103.9) followed
by imprisonment (OR=8.9, 95% CI, 2.97-26.6). However, by logistic regression
only history of IV drug abuse was obtained as significant (p<0.05).
Hepatitis C is growing and emerging as the most prevalent
chronic, viral hepatic disease, so further consideration of risk factors and
routes of transmission is crucial for appropriate planning for, and preventing,
treating, and controlling hepatitis C. IV drug abusers as the most important
group need special consideration and surveillance in order to cut infection
chain and decrease the disease incidence.
Full article at: http://goo.gl/7zb3Vy
By:
- 1Faculty, Department of Community Medicine, Shahrekord University of Medical Sciences , Shahrekord, IR Iran.
- 2Faculty, Department of Infectious Diseases, Shahrekord University of Medical Sciences , Shahrekord, IR Iran .
- 3Faculty, Department of Microbiology, Shahrekord University of Medical Sciences , Shahrekord, IR Iran .
- 4Central Disease Control Unit, Shahrekord University of Medical Sciences , Shahrekord, IR Iran .
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