Late presentation (LP) for HIV care across Europe remains a
significant issue. We provide a cross-European update from 34 countries on the
prevalence and risk factors of LP for 2010–2013. People aged ≥ 16 presenting
for HIV care (earliest of HIV-diagnosis, first clinic visit or cohort
enrolment) after 1 January 2010 with available CD4 count within six months of
presentation were included.
LP was defined as presentation with a CD4
count < 350/mm3 or an AIDS defining event
(at any CD4), in the six months following HIV diagnosis. Logistic regression
investigated changes in LP over time.
A total of 30,454 people were included.
The median CD4 count at presentation was 368/mm3 (interquartile range (IQR)
193–555/mm3), with no change over time (p = 0.70). In 2010, 4,775/10,766
(47.5%) were LP whereas in 2013, 1,642/3,375 (48.7%) were LP (p = 0.63). LP was
most common in central Europe (4,791/9,625, 49.8%), followed by northern
(5,704/11,692; 48.8%), southern (3,550/7,760; 45.8%) and eastern Europe
(541/1,377; 38.3%; p < 0.0001).
There was a significant increase in LP in
male and female people who inject drugs (PWID) (adjusted odds ratio (aOR)/year
later 1.16; 95% confidence interval (CI): 1.02–1.32), and a significant decline
in LP in northern Europe (aOR/year later 0.89; 95% CI: 0.85–0.94).
Further
improvements in effective HIV testing strategies, with a focus on vulnerable
groups, are required across the European continent.
Below: Adjusted odds of having no CD4 count information within six months following HIV diagnosis, COHERE study, 2010–2013
COHERE: Collaboration of Observational HIV Epidemiological Research Europe; IQR: interquartile range; MSM: men who have sex with men; PWID: people who inject drugs.
a% represents percentage of total; for example, 15,371/30,454 (50.5%) of the population included were MSM.
b % represents the percentage of late presenters; for example, 5,993/15,371 (39.0%) of MSM were late presenters.
c Delayed entry into care was defined as more than three months between HIV diagnosis and first visit to clinic, in people with both dates recorded (n = 27,998).
d Baseline was defined as the earliest of HIV test, first study visit or cohort enrolment.
Below: Changes over time in late presentation by HIV exposure groups, COHERE study, 2010–2013 (n=30,454)
Below: Changes over time in late presentation by region of care in Europe, COHERE study, 2010–2013 (N=30,454)
Full article at: http://goo.gl/tLt6LP
By: Analysis and Writing Committee: Amanda Mocroft, Jens
Lundgren, Andrea Antinori, Antonella d’Arminio Monforte, Johanna Brännström,
Fabrice Bonnet, Norbert Brockmeyer, Jordi Casabona, Antonella Castagna,
Dominique Costagliola, Stéphane De Wit, Gerd Fätkenheuer, Hansjakob Furrer,
Corinne Jadand, Anne Johnson, Mario Lazanas, Catherine Leport, Santiago Moreno,
Christina Mussini, Niels Obel, Frank Post, Peter Reiss, Caroline Sabin, Adriane
Skaletz-Rorowski, Ignacio Suarez-Loano, Carlo Torti, Josiane Warszawski, Linda
Wittkop, Robert Zangerle, Genevieve Chene, Dorthe Raben, Ole Kirk.
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