To investigate the origins of
HIV transmission and phylogenetic dynamics among men who have sex with men
(MSM), a total of 1205 newly diagnosed HIV-infected 16–25 year-olds were
recruited in 13 provinces across China between 2009 and 2014.
Based on phylogenetic
analyses of partial pol sequences,
HIV-1 subtypes including CRF01_AE (45.3%), CRF07_BC (37.8%), subtype B (6.1%),
and B’ (3.7%), as well as some other recombinants (7.1%) were identified. In
addition to two distinct CRF01_AE clusters [cluster 4 (33.7%, 406/1205) and
cluster 5 (7.1%, 85/1205)], we identified a new CRF07_BC cluster (cluster 1)
(36.0%, 434/1205), which entered Chinese MSMs in 2004, and had been rapidly
spreading since about 2004, which indicating the third wave of the HIV epidemic
among the population. Moreover, two new clusters of CRF_01B recombinants were
found in this study.
The complexities of HIV subtypes and recombinants strongly
supports the necessity for a comprehensive study about risk behaviors and their
relationship with increasing HIV epidemic subtypes among the MSM group.
Implementation and evaluation of comprehensive harm reduction strategies in
Chinese MSM are urgently needed.
Below: Baysian skyline plot was
estimated to reconstruct the demographic history of the five major clusters
(n ≥ 45) among MSM in China. The
x axis is the time in units of years, and the y axis is equal to the effective
population size. The thick solid line is the mean estimate and the 95% HPD
credible region is shown by blue areas.
Full article at: http://goo.gl/VormW5
By: Zheng Li,1,* Lingjie Liao,1,* Yi Feng,1 Jing Zhang,1 Jing Yan,1 Cui He,1 Wei Xu,1 Yuhua Ruan,1 Hui Xing,a,1 and Yiming Shaob,1
1State Key Laboratory of Infectious Disease
Prevention and Control, National Center for AIDS/STD Control and Prevention,
Chinese Center for Disease Control and Prevention, Collaborative Innovation
Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China
aEmail: nc.sdiaanihc@hgnix
bEmail: nc.ude.umjb@oahsy
*These authors contributed equally to this work.
More at: https://twitter.com/hiv_insight
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