Detection of High-Risk Human Papillomavirus Using Menstrual Blood in Women with High-Grade Squamous Intraepithelial Lesions or High-Risk Human Papillomavirus Infections
AIM:
Few studies
have reported that human papillomavirus (HPV) tests using menstrual blood (MB)
may be a convenient and effective screening modality for cervical cancer.
Therefore, we aimed to investigate the efficacy of detecting high-risk (HR)-HPV
from MB in women with high-grade squamous intraepithelial lesions or HR-HPV
infections dependent on menstrual days.
MATERIALS AND METHODS:
In
this prospective exploratory pilot study, a clinical trial was conducted in 19
women. On enrollment into the study, gynecologists collected cervical cells. On
the first and second day of menstruation, MB was self-collected by patients
using a sanitary pad with a filter. The distribution of HPVs from MB and the
accuracy of menstrual HR-HPV tests were evaluated using HPV genotyping. The
agreement rate of detecting HR-HPVs using cervical and MB samples was also
investigated.
RESULTS:
The
sensitivity, specificity, positive and negative predictive values of the MB
HR-HPV test for detecting cervical intraepithelial neoplasia (CIN) 3 or worse
were 87.5%, 45.5%, 53.8%, and 83.3%, respectively, during both menstrual cycle
day (MCD) 1 and 2 and MCD 1 only; and 62.5%, 27.3%, 38.5%, and 50.0%,
respectively, during MCD 2 only. For CIN 3 or worse, the agreement rate between
positive cervical and MB HR-HPV test results was 87.5% during MCD 1 and 62.5%
during MCD 2.
CONCLUSIONS:
We
demonstrated the possibility of using the MB HPV test as a screening modality
for cervical cancer.
By: Lee B1, Cho HY2, Jeon KJ1, Kim K1,3, Lee JR1,3, Moon JJ4, No JH1,3, Kim YB1,3.
- 1Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-Si, Gyeonggi-Do, Republic of Korea.
- 2Department of Obstetrics and Gynecology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-Si, Gyeonggi-do, Republic of Korea.
- 3Seoul National University, School of Medicine, Seoul, Republic of Korea.
- 4Goodgene Inc. Koyang-Si, Gyeonggi-do, Republic of Korea.
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