Background
Gene-environment
interactions are important for understanding alterations in human brain
function. The loudness dependence of auditory evoked potential (LDAEP) is known
to reflect central serotonergic activity. Single nucleotide polymorphisms
(SNPs) in the 5-HT3A serotonin receptor gene are associated with psychiatric
disorders. This study aimed to investigate the effect between 5-HT3A receptor
gene polymorphisms and childhood sexual trauma on the LDAEP as an
electrophysiological marker in healthy subjects.
Methods
A
total of 206 healthy subjects were recruited and evaluated using the childhood
trauma questionnaire (CTQ) and hospital anxiety and depression scale (HADS).
Peak-to-peak N1/P2 was measured at five stimulus intensities, and the LDAEP was
calculated as the linear-regression slope. In addition, the rs1062613 SNPs of
5-HT3A (CC, CT, and TT) were analyzed in healthy subjects.
Results
There
was a significant interaction between scores on the CTQ-sexual abuse subscale
and 5-HT3A genotype on the LDAEP. Subjects with the CC polymorphism had a
significantly higher LDEAP than T carriers in the sexually abused group. In
addition, CC genotype subjects in the sexually abused group showed a
significantly higher LDAEP compared with CC genotype subjects in the non-sexually
abused group.
Conclusions
Our findings suggest that people with the CC polymorphism
of the 5-HT3A gene have a greater risk of developing mental health problems if
they have experienced childhood sexual abuse, possibly due to low central
serotonin activity. Conversely, the T polymorphism may be protective against
any central serotonergic changes following childhood sexual trauma.
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By:
Kuk-In Jang, Jeong-Ho Chae
Department of Biomedicine &
Health Sciences, The Catholic University of Korea, College of Medicine, Seoul,
Korea
Seung-Hwan Lee
Department of Psychiatry, Inje
University College of Medicine, Ilsan Paik Hospital, Goyang, Korea
Kuk-In Jang, Seung-Hwan Lee
Clinical Emotion and Cognition
Research Laboratory, Inje University, Goyang, Korea
Hyu Jung Huh, Jeong-Ho Chae
Department of Psychiatry, Seoul
St. Mary's Hospital, The Catholic University of Korea, College of Medicine,
Seoul, Korea
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