Using Conjoint Analysis to Determine the Impact of Product & User Characteristics on Acceptability of Rectal Microbicides for HIV Prevention among Peruvian Men Who Have Sex with Men
who have sex with men (MSM) are in need of novel and acceptable HIV prevention
interventions. In Peru, a Phase II clinical trial was recently completed
evaluating rectally applied tenofovir gel among Peruvian MSM and transgender
women. If deemed safe and acceptable, the product could move into efficacy
testing, but acceptability data for similar products are needed now in order to
prepare for future implementation. Peru is in need of expanded, national
acceptability data among likely users.
conjoint analysis of an online cross-sectional survey taken by 1008 Peruvian
MSM and transgender women, we tested the acceptability of eight hypothetical
rectal microbicide (RM) products comprising six, dual-value attributes. We also
assessed the relationship of select product attributes with sample
acceptability was found for a RM that was 90% effective, used before and after
sex, without side effects, costing approximately $0.30, had no prescription
requirement and had a single-use applicator. Product effectiveness and presence
of side effects were the factors most likely to drive RM acceptance and use.
Education, sexual orientation, sexual role and concern for HIV infection were
also related to aspects of RM acceptability.
acceptability was high, confirming the results of earlier, smaller studies and
placing confidence in the acceptability of RMs. Analysis of the relationships
with product attributes and sample characteristics underscore the need to
consider the impact of factors such as sexual orientation, sexual role, level
of education and concern for HIV acquisition on RM acceptability.
1Columbia University College of Physicians & Surgeons, New York, New York, USA.
2Epicentro Salud, Lima, Peru Socios En Salud, Lima, Peru.
3Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
4Asociación Civil Impacta Salud y Educación, Lima, Peru.
5Columbia University College of Physicians & Surgeons, New York, New York, USA Department of Medicine, Division of Infectious Disease, Columbia University College of Physicians & Surgeons, New York, New York, USA.
6Asociación Civil Impacta Salud y Educación, Lima, Peru Department of Global Health, University of Washington, Seattle, Washington, USA.