Friday, January 15, 2016

Adult Functional Outcomes of Common Childhood Psychiatric Problems: A Prospective, Longitudinal Study

Context
Psychiatric problems are among the most common health problems of childhood.

Objective
To test whether these health problems adversely affect adult functioning even if the problems themselves do not persist.

Design
Prospective, population-based study of 1420 participants assessed with structured interviews up to 6 times in childhood (ages 9 to 16; 6674 observations) for common psychiatric diagnoses and subthreshold psychiatric problems.

Main outcome measure
Participants were then assessed 3 times in young adulthood (ages 19, 21, and 24–26; 3215 observations of 1273 subjects) for adverse outcomes related to health, legal, financial, and social functioning.

Results
Participants with a childhood disorder had 6 times higher odds of at least one adverse adult outcome as compared to those with no history of psychiatric problems and 9 times higher odds of 2 or more such indicators (1 indicator: 59.5% vs. 19.9%, p <0.001; 2+ indicators: 34.2% vs. 5.6%, p <0.001). These associations persisted after statistically controlling for childhood psychosocial hardships and adult psychiatric problems. Risk was not limited to those with a diagnosis: participants with subthreshold psychiatric problems had 3 times higher odds of adult adverse outcomes and 5 time higher odds of 2 or more outcomes (1 indicator: 41.9% vs. 19.9%, p <0.001; 2+ indicators: 23.2% vs. 5.6%, p <0.001). The best diagnostic predictor of adverse outcomes was cumulative childhood exposure to psychiatric disorders.

Conclusions
Common, typically moderately-impairing, childhood psychiatric problems are associated with a disrupted transition to adulthood even if the problems do not persist into adulthood and even if the problems are subthreshold. Such problems provide potential target for public health efforts to ameliorate adult suffering and morbidity.

Below:  Associations between adult outcomes and childhood diagnostic groups







Full article at:   http://goo.gl/tK7ttb

William E. Copeland, Department of Psychiatry and Behavioral Sciences at Duke University Medical Center;
Dieter Wolke: ku.ca.kciwraw@ekloW.D; Lilly Shanahan: ude.cnu@nahanahs_yllil; E. Jane Costello: ude.ekud@olletsoc.htebazile
Corresponding author: William E. Copeland, Ph.D., Center for Developmental Epidemiology, Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Box 3454, Durham NC 27710, Email: ude.ekud@dnalepoc.mailliw, Phone: (919) 687-4686, Fax: (919) 687-4737






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