Declining & Rebounding Unhealthy Alcohol Consumption During the First Year of HIV Care in Rural Uganda, Using Phosphatidylethanol to Augment Self-Report
AIMS:
We
examined whether unhealthy alcohol consumption, which negatively impacts HIV outcomes, changes after HIV care entry overall and by several factors. We
also compared using phosphatidylethanol (PEth, an alcohol biomarker) to augment
self-report to using self-report alone.
DESIGN:
A
prospective 1-year observational cohort study with quarterly visits.
SETTING:
Large
rural HIV clinic
in Mbarara, Uganda.
PARTICIPANTS:
A
total of 208 adults (89 women and 119 men) entering HIV care, reporting any prior year alcohol
consumption.
MEASUREMENTS:
Unhealthy
drinking was PEth+ (≥ 50 ng/ml) or Alcohol Use Disorders Identification
Test-Consumption+ (AUDIT-C+, over 3 months, women ≥ 3; men ≥ 4). We calculated
adjusted odds ratios (AOR) for unhealthy drinking per month since baseline, and
interactions of month since baseline with perceived health, number of HIV symptoms, antiretroviral therapy (ART), gender
and self-reported prior unhealthy alcohol use.
FINDINGS:
The
majority of participants (64%) were unhealthy drinkers (PEth+ or AUDIT-C+) at
baseline. There was no significant trend in unhealthy drinking overall
[per-month AOR: 1.01; 95% confidence interval (CI) = 0.94-1.07], while the
per-month AORs were 0.91 (95% CI = 0.83-1.00) and 1.11 (95% CI = 1.01-1.22)
when participants were not yet on ART and on ART, respectively (interaction
P-value < 0.01). In contrast, 44% were AUDIT-C+; the per-month AORs for
being AUDIT-C+ were 0.89 (95% CI = 0.85-0.95) overall, and 0.84 (95%
CI = 0.78-0.91) and 0.97 (95% CI = 0.89-1.05) when participants were not on and
were on ART, respectively.
CONCLUSIONS:
Unhealthy
alcohol use among Ugandan adults entering HIV care
declines prior to the start of anti-retroviral therapy but rebounds with time.
Augmenting self-reported alcohol use with biomarkers increases the ability of
current alcohol use measurements to detect unhealthy alcohol use.
- 1University of California, Department of Medicine, San Francisco, CA, USA.
- 2University of California, Department of Epidemiology and Biostatistics, San Francisco, CA, USA.
- 3Mbarara University of Sciences and Technology, Faculty of Medicine, Mbarara, Uganda.
- 4University of California, Department of Community Health Systems, San Francisco, CA, USA.
- Addiction. 2016 Feb;111(2):272-9. doi: 10.1111/add.13173. Epub 2015 Nov 5.
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