Background.
HIV infected
women have higher rates of infertility.
Objective.
The purpose of this
literature review is to evaluate the effectiveness of fresh IVF/ICSI cycles in
HIV infected women.
Materials and Methods.
A search of the PubMed database was
performed to identify studies assessing fresh nondonor oocyte IVF/ICSI cycle
outcomes of serodiscordant couples with an HIV infected female partner.
Results
and Discussion.
Ten studies met the inclusion criteria. Whenever a comparison
with a control group was available, with the exception of one case, ovarian
stimulation cancelation rate was higher and pregnancy rate (PR) was lower in
HIV infected women. However, statistically significant differences in both
rates were only seen in one and two studies, respectively. A number of
noncontrolled sources of bias for IVF outcome were identified. This fact, added
to the small size of samples studied and heterogeneity in study design and
methodology, still hampers the performance of a meta-analysis on the issue.
Conclusion.
Prospective matched case-control studies are necessary for the
understanding of the specific effects of HIV infection on ovarian response and
ART outcome.
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By:
- 1Maternidade Dr. Alfredo da Costa, Rua Viriato, 1069-089 Lisboa, Portugal.
- 2Fetal Maternal Department, Maternidade Dr. Alfredo da Costa, Lisbon, Portugal.
- 3Instituto Valenciano de Infertilidade (IVI-Lisboa), Lisbon, Portugal.
- Infect Dis Obstet Gynecol. 2015;2015:517208. doi: 10.1155/2015/517208. Epub 2015 Dec 8.
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