Inhalation by vaporization is
a promising application mode for cannabis in medicine.
An in vitro validation
of 5 commercial vaporizers was performed with THC-type and CBD-type cannabis.
Gas chromatography/mass spectrometry was used to determine recoveries of total
THC (THCtot) and total CBD (CBDtot) in the
vapor. High-performance liquid chromatography with photodiode array detection
was used for the quantitation of acidic cannabinoids in the residue and to
calculate decarboxylation efficiencies.
Recoveries of THCtot and CBDtot in the vapor of 4 electrically-driven vaporizers were
58.4 and 51.4%, 66.8 and 56.1%, 82.7 and 70.0% and 54.6 and 56.7% for Volcano
Medic®, Plenty Vaporizer®, Arizer
Solo® and DaVinci Vaporizer®,
respectively. Decarboxylation efficiency was excellent for THC (≥ 97.3%) and
CBD (≥ 94.6%).
The gas-powered Vape-or-Smoke™ showed recoveries of THCtot and CBDtot in the vapor of 55.9 and 45.9%, respectively, and a
decarboxylation efficiency of ≥ 87.7 for both cannabinoids. However, combustion
of cannabis was observed with this device. Temperature-controlled,
electrically-driven vaporizers efficiently decarboxylate inactive acidic
cannabinoids and reliably release their corresponding neutral, active
cannabinoids. Thus, they offer a promising application mode for the safe and
efficient administration of medicinal cannabis.
Below: Percentage of total cannabinoids found in the vapor, residue and device parts of Volcano Medic®, Plenty Vaporizer®, Arizer Solo®, DaVinci Vaporizer®, and Vape-or-Smoke™.
Below: Percentage of total cannabinoids found in the vapor, residue and device parts of Volcano Medic®, Plenty Vaporizer®, Arizer Solo®, DaVinci Vaporizer®, and Vape-or-Smoke™.
Depicted are the mean values + 1 SD. Bars, left to right:
THC from THC-type cannabis; THC from CBD-type cannabis; CBD from CBD-type
cannabis; THC standard; CBD standard.
Full article at: http://goo.gl/xUlCxs
By:
Christian Lanz, Umut Soydaner, Rudolf Brenneisen
Department of Clinical Research, Laboratory of
Phytopharmacology, Bioanalytics and Pharmacokinetics, University of Bern, Bern,
Switzerland
Johan Mattsson
Center of Laboratory Medicine, University Institute of Clinical
Chemistry, Inselspital, University Hospital Bern, Bern, Switzerland
More at: https://twitter.com/hiv insight
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