Background
HPV infects multiple sites in the epithelium,
including the genitals and oral cavity. The relation between genital and oral
infections and serum antibodies can help explain the natural history and
epidemiology of HPV.
Methods
We analyzed HPV data from NHANES derived from
self-collected vaginal swabs (women ages 14–59, 2003–12), oral rinses (men and
women 14–69, 2009–12), and serum (men and women 14-59, 2003–10).
Results
Type-concordance of cervicogenital and oral infections
in women was found to vary widely by age. Prevalence of oral infections with
type-concordant antibodies was low but varied by sex: 0.2 % (95 % CI 0.0–0.8)
for women vs 0.8 % (95 % CI 0.4–1.3) for men. Vaccination was associated with a
reduced risk of cervicogenital infection for vaccine genotypes among ages 14–17
(0.2 (95 % CI 0.1–0.8)) and 18–24 (0.2 (95 % CI 0.1–0.3). Seroprevalence trends
in women showed a dramatic increase for recent birth cohorts, likely due to
vaccination. By contrast, trends for men remained relatively constant.
Age-specific cervicogenital prevalence showed a consistent peak in the late
teens and twenties. Relative cervicogenital prevalence has largely been
decreasing since the 1940–50 birth cohort.
Below: Oral and cervicogenital HPV prevalence and type-concordance
for women ages 14–59. Oral (a and b) and genital (c and d) prevalence are given by age and race in 2009–10
and 2011–12 and are separated into type-concordant and non-type-concordant
infections. Type-concordant infections represent a simultaneous oral and
cervicogenital infection of the same genotype
Conclusions
There are complex patterns in HPV prevalence trends
and type-concordance across infection sites and serum antibodies. A multisite
sampling scheme is needed to better understand the epidemiology and natural
history of HPV.
Full article at: http://goo.gl/KqxP9O
By:
Department of Epidemiology,
University of Michigan
More at: https://twitter.com/hiv
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