AIMS:
To
determine whether the provision of contingency management using financial
incentives to improve hepatitis B vaccine completion in people who inject drugs
entering community treatment represents a cost-effective use of healthcare
resources.
DESIGN:
A
probabilistic cost-effectiveness analysis was conducted, using a decision-tree
to estimate the short-term clinical and healthcare cost impact of the vaccination
strategies, followed by a Markov process to evaluate the long-term clinical
consequences and costs associated with hepatitis B infection.
SETTINGS AND PARTICIPANTS:
Data
on attendance to vaccination from a UK cluster randomised trial.
INTERVENTION:
Two
contingency management options were examined in the trial: fixed vs. escalating
schedule financial incentives.
MEASUREMENT:
Lifetime
healthcare costs and quality-adjusted life years discounted at 3.5% annually;
incremental cost-effectiveness ratios.
FINDINGS:
The
resulting estimate for the incremental lifetime healthcare cost of the
contingency management strategy versus usual care was £22 (95% CI: -£12 to £40)
per person offered the incentive. For 1,000 people offered the incentive, the
incremental reduction in numbers of hepatitis B infections avoided over their
lifetime was estimated at 19 (95% CI: 8 to 30). The probabilistic incremental
cost per quality adjusted life year gained of the contingency management
programme was estimated to be £6,738 (95% CI: £6,297 to £7,172), with an 89%
probability of being considered cost-effective at a threshold of £20,000 per
quality-adjusted life years gained (98% at £30,000).
CONCLUSIONS:
Using
financial incentives to increase hepatitis B vaccination completion in people
who inject drugs could be a cost-effective use of healthcare resources in the
UK as long as the incidence remains above 1.2%.
By: Rafia R1, Dodd PJ1, Brennan A1, Meier PS2, Hope VD3, Ncube F3, Byford S4, Tie H4, Metrebian N5, Hellier J6, Weaver T7, Strang J5.
- 1Health Economics and Decision Science (HEDS), School of Health and Related Research (ScHARR), University of Sheffield.
- 2Section of Public Health, School of Health and Related Research (ScHARR), University of Sheffield.
- 3Injecting Drug Use Team, HIV & STI Department, Centre for Infectious Disease Surveillance and Control, Public Health England (PHE).
- 4Centre for the Economics of Mental and Physical Health, King's College London.
- 5National Addiction Centre, Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London.
- 6Department of Biostatistics, King's College London.
- 7Department of Mental Health, Social work and Integrative Medicine, Middlesex University.
- Addiction. 2016 Mar 18. doi: 10.1111/add.13385.
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