Anal human papillomavirus
(HPV) infection, which is linked to anal warts and anal cancer, is common among
men who have sex with men (MSM), especially among those HIV positives. MSM aged
18 years or older were recruited from mainland China.
Blood and anal cytologic
samples were collected for HIV-1 serological test and HPV genotyping. A total
of 889 eligible participations were included. The genotyping results of HPV
were available for 822 participants (92.46%), 65.32% of which were positive for
the targeted 37 HPV types.
Prevalence of infection with any type of HPV was
higher among HIV-infected participants (82.69%) as compared to HIV-uninfected
participants (62.81%) (p < 0.01). HPV06 (15.45%), HPV18(13.50%), HPV16
(11.44%), and HPV11 (10.71%) were the most frequent types identified in the
study population. Ever had paid sex with man was found to be independent
predictor for HPV positivity with an adjusted odds ratios (OR) of 2.34
(1.16–4.74). Anal HPV positivity was observed to be independently associated with
HIV infection with an adjusted OR of 3.03 (1.76–5.21) in the study population.
In conclusion, the prevalence of anal HPV infection was observed to be common
among MSM from mainland China, and it was significantly associated with the
status of HIV infection.
Full article at: http://goo.gl/h1a73Q
By: Xiangwei Li,1,* Mufei Li,1,* Yu Yang,2 Xiang Zhong,3 Boxuan Feng,1 Henan Xin,1 Zhen Li,1 Qi Jin,a,1 and Lei Gaob,1
1MOH Key Laboratory of Systems Biology of
Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences
& Peking Union Medical College, Beijing, China
2Department of Epidemiology and
Biostatistics, School of Public Health, Peking University Health Science
Centre, Beijing, China
3MSD China Holding Co., Ltd, Beijing, China
aEmail: nc.ca.smacbpi@iqnij
bEmail: nc.ca.smacbpi@ieloag
*These authors contributed equally to this work.
More at: https://twitter.com/hiv insight
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