Purpose
Data on the prevalence of
dyslipidaemia and associated risk factors in HIV-infected patients from
sub-Saharan Africa is sparse. We performed a cross-sectional analysis in a
cohort of HIV-infected South African adults.
Methods
We studied HIV-infected
patients who were either antiretroviral therapy (ART)-naive or receiving
non-nucleoside reverse transcriptase inhibitor (NNRTI)-based or protease
inhibitor (PI)-based ART. Evaluation included fasting lipograms, oral glucose
tolerance tests and clinical anthropometry. Dyslipidemia was defined using the
NCEP ATPIII guidelines.
Results
The median age of the
participants was 34 years (range 19–68 years) and 78% were women. The
prevalence of dyslipidemia in 406 ART-naive and 551 participants on ART was
90.0% and 85%, respectively. Low HDL-cholesterol (HDLC) was the most common
abnormality [290/406 (71%) ART-naïve and 237/551 (43%) ART- participants].
Participants on ART had higher triglycerides (TG), total cholesterol (TC),
LDL-cholesterol (LDLC) and HDLC than the ART-naïve group. Severe dyslipidaemia,
(LDLC> 4.9 mmol/L or TG >5.0 mmol/L) was present in <5% of
participants. In multivariate analyses there were complex associations between
age, gender, type and duration of ART and body composition and LDLC, HDLC and
TG, which differed between ART-naïve and ART-participants.
Conclusion
Participants
on ART had higher TG, TC, LDLC and HDLC than those who were ART-naïve but
severe lipid abnormalities requiring evaluation and treatment were uncommon.
Below: Distribution of lipid abnormalities in treatment naïve (A) and participants receiving ART (B).
Below: Distribution of lipid abnormalities in treatment naïve (A) and participants receiving ART (B).
The left-sided Venn diagrams indicate % with dyslipidaemia.
The right-sided diagrams indicate the individual lipid abnormalities in
dyslipidaemic participants. Percentages in the right diagrams refer to %
dyslipidaemic participants. Rounding accounts for percentages not equal to
100.
Full article at: http://goo.gl/HqvLhU
By:
Divisions of Diabetic Medicine and Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Department of Statistical Sciences, University of Cape Town, Cape Town, South
Africa
Division of Clinical Pharmacology, Department of Medicine, University of Cape
Town, Cape Town, South Africa
Division of Lipidology, Department of Medicine, University of Cape Town, Cape
Town, South Africa
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