Association of Injection Drug Use with Incidence of HIV-Associated Non-AIDS-Related Morbidity by Age, 1995-2014
OBJECTIVE:
Incidence
of HIV-associated non-AIDS (HANA) related comorbidities is increasing in
HIV-infected individuals. Our objective was to estimate the risk of HANA
comorbidity associated with history of injection drug use (IDU), correctly
accounting for higher death rates among people who inject drugs (PWID).
DESIGN:
We
followed HIV-infected persons aged 25-59 years who enrolled in the Johns
Hopkins HIV Clinical Cohort between 1995 and May 2014, from enrollment until
HANA comorbidity diagnosis, death, age 60 or administrative censoring.
METHODS:
We
compared cumulative incidence ("risk"), by age, of validated diagnoses
of HANA comorbidities among HIV-infected PWID and non-IDU; specifically, we
considered end-stage renal disease (ESRD), end-stage liver disease (ESLD),
myocardial infarction (MI), stroke, and non-AIDS-defining cancer. We used
competing risk methods appropriate to account for death, standardized to the
marginal distribution of baseline covariates and adjusted for potential
differential loss-to-clinic.
RESULTS:
Of 5,490
patients included in this analysis, 37% reported IDU as an HIV transmission
risk. By age 55 years, PWID had higher risk of ESLD (risk difference = 6.8, 95%
CI: -1.9, 15.5) and ESRD (risk difference = 11.1, 95% CI: 1.2, 21.0) than did
non-IDU. Risk of MI and stroke were similar among PWID and non-IDU. Risk of
non-AIDS-defining cancer was lower among PWID than among non-IDU (risk
difference at 55 years: -4.9, 95% CI: -11.2, 1.3).
CONCLUSIONS:
Not
all HANA comorbidities occur with higher incidence in PWID compared to non-IDU.
However, higher incidence of ESRD and ESLD among PWID highlights the importance
of recognition and management of markers of these comorbidities in early stages
among PWID.
- 1 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
- School of Medicine, Johns Hopkins University, Baltimore, MD.
- AIDS. 2016 Mar 16.
No comments:
Post a Comment