We examined the relationship
between residential eviction and exhibiting detectable plasma HIV-1 RNA viral
load (VL) among a prospective cohort of antiretroviral therapy (ART)-exposed
HIV-seropositive people who use illicit drugs (PWUD) in Vancouver, Canada.
We used multivariable generalized estimating equations to estimate the effect of residential eviction on detectable VL and examine ART adherence as a mediating variable.
Between June 2007 and May 2014, 705 ART-exposed participants were included in the study, among whom 500 (70.9 %) experienced at least one period of detectable VL. In a time-updated multivariable model, eviction independently increased the odds of detectable VL among those who were homeless as well as not homeless post eviction. The results of mediation analyses suggest that this association was mediated by incomplete ART adherence.
These findings suggest the need for further development and evaluation of interventions to prevent evictions and promote ART adherence among PWUD facing eviction.
We used multivariable generalized estimating equations to estimate the effect of residential eviction on detectable VL and examine ART adherence as a mediating variable.
Between June 2007 and May 2014, 705 ART-exposed participants were included in the study, among whom 500 (70.9 %) experienced at least one period of detectable VL. In a time-updated multivariable model, eviction independently increased the odds of detectable VL among those who were homeless as well as not homeless post eviction. The results of mediation analyses suggest that this association was mediated by incomplete ART adherence.
These findings suggest the need for further development and evaluation of interventions to prevent evictions and promote ART adherence among PWUD facing eviction.
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By:
1British Columbia Centre for Excellence in HIV/AIDS,
St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
2School of Population and Public Health, University of
British Columbia, 2206 E Mall, Vancouver, BC, V6T 1Z9, Canada.
3Department of Medicine, University of British
Columbia, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.
4British Columbia Centre for Excellence in HIV/AIDS,
St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
uhri-mjsm@cfenet.ubc.ca.
5Department of Medicine, University of British
Columbia, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.
uhri-mjsm@cfenet.ubc.ca.
AIDS Behav. 2016 Feb 23.
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