Sunday, March 27, 2016

Seroprevalence of HCV Markers among HIV Infected Patients from Curitiba & Metropolitan Region, Brazil

to determine the prevalence and epidemiological factors associated with hepatitis (HCV) coinfection in human immunodeficiency virus (HIV) patients from Curitiba and the metropolitan region.

a study with 303 HIV+ patients, mean age 41.2 years (18-73); 50.5% men, followed at the Hospital de Clínicas, Universidade Federal do Paraná, between April 2008 and March 2009. Clinical and epidemiological data were obtained through questionnaires and retrospective analysis of medical records. Anti-HCV antibodies were detected by chemiluminescence immunoassay.

a total of 12.9% of HIV+ patients were positive for anti-HCV antibodies, 64.1% were men and 35.9% women, with mean age of 44.5 years (24-66). The frequency of HCV among men was 16.7% and among women 9.1%. HCV prevalence was associated to HIV infection when compared to the general population. The parenteral route of transmission was the most frequent among coinfected patients (46.1%), and the sexual transmission among HIV+/HCV- (71.8%). The frequency of intravenous drug users was higher among the coinfected patients (61.5%) compared to the non coinfected (12.6%).

the prevalence of coinfection with HCV in HIV+ patients is 12.9%, 88 times higher than in the general population in Curitiba. The most frequent route of transmission in the coinfected patients is parenteral, but the sexual route is also representative (34.6%).

Prevalence of HCV/HIV co-infection in different Brazilian geographical regions 
Geographical regionsNHCV-HIV prevalence (Anti-HCV)References
Florianópolis, SC9953.8%Treitinger et al., 199934
São Paulo, SP1,45717.7%Mendes-Corrêa et al., 200141
Rio de Janeiro, RJ2388.9%Ferraz et al., 200242
Campinas, SP23253.8%Pavan et al., 200335
Santos, SP49536.2%Segurado et al., 200421
Londrina, PR78421.0%Morimoto et al., 200522
Manaus, AM7045.0%Braga et al., 200623
Porto Alegre, RS33038.2%Tovo et al., 200625
Cuiabá, MT1,00810.9%Mussi et al., 200726
Botucatu, SP15014.7%Corvino et al., 200743
Belo Horizonte, MG8249.2%Carmo et al., 200844
Belo Horizonte, MG30015.7%Rodrigues et al., 200845
Londrina, PR77821.0%Reiche et al., 200829
São Paulo, SP8,01912.9%Farias et al., 200828
Recife, PE3434.1%Carvalho et al., 200946
São Paulo, SP2,02416.7%Mendes-Corrêa et al., 201040
Santa Maria, RS25031.2%Santos et al., 201030
CE1,29125.4%Távora et al., 201332
Curitiba, PR30312.9%Present study

Full article at:

1Pharmacy Course, UNIBRASIL, Curitiba, PR, Brazil.
2Universidade Federal do paraná, Curitiba, PR, Brazil.
3Hospital das Clínicas, UFPR, Curitiba, PR, Brazil.
4Pathology Department, UFPR, Curitiba, PR, Brazil.
Rev Assoc Med Bras. 2016 Feb;62(1):65-71. doi: 10.1590/1806-9282.62.01.65.

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