The purpose of this study was to assess the risk of abnormal anal cytology in women with known genital squamous intraepithelial lesion (SIL).
This study evaluated 200 women with and without genital SIL who were recruited for anal Pap smears. Women who had abnormal results on equally or over atypical squamous cells of undetermined significance were classified as having abnormal anal cytology. A multiple logistic regression analysis (stepwise) was performed to identify the risk for developing abnormal anal cytology.
Data were analyzed using the SPSS 20.0 program. The average age was 41.09 (±12.64). Of the total participants, 75.5% did not practice anal sex, 91% did not have HPV-infected partners, 92% did not have any anal pathology, and 68.5% did not have anal bleeding. More than half (57.5%) had genital SIL and a significant number developed abnormal anal cytology: 13% in the total sample and 17.4% in women with genital SIL. A significant association was observed between genital SIL and anal SIL (PR=2.46; p=0.03). In the logistic regression model, women having genital intraepithelial lesion were more likely to have abnormal anal Pap smear (aPR=2.81; p=0.02).
This report shows that women with genital SIL must be more closely screened for anal cancer.
Below: Normal (left) and atypical squamous cells of undetermined significance in anal cytology (right)
Full article at: http://goo.gl/QsiG6F
- 1Health Post Graduation Program, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
- 2Department of Obstetric and Gynecology, Faculdade de Medicina Souza Marques, Rio de Janeiro, RJ, Brazil.
- 3Department of Obstetrics and Gynecology, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
- 4Health Post Graduation Program, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Obstetric and Gynecology, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address: firstname.lastname@example.org.
- Braz J Infect Dis. 2016 Mar 29. pii: S1413-8670(16)30041-1. doi: 10.1016/j.bjid.2016.01.008.
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