Highlights
- To achieve the same impact on FSW HIV prevalence as increasing condom use by 1%, the coverage of PrEP has to increase by >2%.
- The relative impact of PrEP compared to condoms increases for scenarios where pimps contribute to HIV transmission.
- Condom promotion interventions should remain the mainstay HIV prevention strategy for FSWs.
- PrEP should only be implemented to fill prevention gaps where condoms cannot be used.
It is important to remember that condoms
also have other benefits such as reducing the incidence of sexually transmitted
infections and preventing pregnancy. A dynamic deterministic model of HIV
transmission amongst FSWs, their clients and other male partners (termed
'pimps') was used to compare the protection provided by PrEP for HIV-negative
FSWs with FSWs increasing their condom use with clients and/or pimps. For
different HIV prevalence scenarios, levels of pimp interaction, and baseline
condom use, we estimated the coverage of PrEP that gives the same reduction in
endemic FSW HIV prevalence or HIV infections averted as different increases in
condom use.
To achieve the same impact on FSW HIV prevalence as increasing
condom use by 1%, the coverage of PrEP has to increase by >2%. The relative
impact of PrEP increases for scenarios where pimps contribute to HIV
transmission, but not greatly, and decreases with higher baseline condom use.
In terms of HIV infections averted over 10 years, the relative impact of PrEP
compared to condoms was reduced, with a >3% increase in PrEP coverage
achieving the same impact as a 1% increase in condom use.
Condom promotion interventions
should remain the mainstay HIV prevention strategy for FSWs, with PrEP only
being implemented once condom interventions have been maximised or to fill
prevention gaps where condoms cannot be used.
Below: The relative impact of PrEP compared to condoms for decreasing the endemic FSW HIV prevalence (a) or averting HIV infections (b) after 10 years for different baseline FSW HIV prevalences, with no condom or PrEP use at baseline.
Below: The relative impact of PrEP compared to condoms for decreasing the endemic FSW HIV prevalence (a) or averting HIV infections (b) after 10 years for different baseline FSW HIV prevalences, with no condom or PrEP use at baseline.
Below: Sensitivity analysis on how the relative impact of PrEP changes for specific changes in model parameters
Full article at: http://goo.gl/hsnL86
Full article at: http://goo.gl/hsnL86
By: Mukandavire Z1, Mitchell KM2, Vickerman P3.
- 1Social and Mathematical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK. Electronic address: Zindoga.Mukandavire@lshtm.ac.uk.
- 2Department of Infectious Disease Epidemiology, Imperial College London, London, UK. Electronic address: Kate.Mitchell@imperial.ac.uk.
- 3School of Social and Community Medicine, University of Bristol, Bristol, UK. Electronic address: Peter.Vickerman@bristol.ac.uk.
- Epidemics. 2016 Mar;14:62-70. doi: 10.1016/j.epidem.2015.10.002. Epub 2015 Nov 12.
More at: https://twitter.com/hiv insight
No comments:
Post a Comment