Showing posts with label non-occupational post-exposure prophylaxis. Show all posts
Showing posts with label non-occupational post-exposure prophylaxis. Show all posts

Monday, December 28, 2015

Assessing the Feasibility of Police Initiation of HIV Post-Exposure Prophylaxis for Sexual Violence Survivors in Lusaka, Zambia

Globally, more than 1 in 3 women have experienced physical or sexual violence (SV) from intimate partners or SV from non-partners [1]. Furthermore, over 10% of all girls are estimated to have experienced a forced sexual act, with the highest rates of SV against girls found in sub-Saharan Africa [2].

Although public recognition of SV is growing in Zambia, reliable data on the nature and extent of such violence is limited. Approximately 20% of Zambian women aged 15 to 49 have experienced some form of sexual violence; however, this is likely underestimated due to underreporting [3]. Previous research in Zambia suggests that exposure to SV is equally pervasive among adolescent girls [4,5].

The risks associated with SV, especially among young women, are numerous. Immediate health consequences include unwanted pregnancy, physical trauma, mental distress and acquisition of HIV and other sexually-transmitted infections. The linkage between sexual and gender-based violence (SGBV) and risk of HIV has been well documented in Africa and is especially pronounced in countries with high HIV prevalence, such as Zambia [3,6-8].

Growing awareness of these negative consequences of SGBV led the Government of Zambia to develop a set of national guidelines for the management of SGBV, highlighting the need for a response system linking the health, police, and social services sectors. A critical component of this response is the prevention of HIV infection in SV survivors through the provision of preventive anti-retroviral therapy, or HIV post-exposure prophylaxis (PEP). The initial dose of PEP must be taken within 72 hours of exposure to HIV [9].

Given the time sensitivity of PEP and the fact that police and health services are often the first points of contact for SV survivors, strong coordination between these two sectors is central to the effective medical management of SV cases in Zambia [10]. Building on the results of previous research in Zambia, which demonstrated that trained Victim Support Unit (VSU) police officers could effectively administer the emergency contraception pill to SV survivors, the Population Council, Zambia Police Service, and Ministry of Health aimed to assess the feasibility of having trained VSU police officers safely and effectively provide a PEP starter dose to SV survivors with immediate referral to comprehensive medical services [10].

Below:  Police delivery of PEP (November 2012 - October 2013)



Full article at:   http://goo.gl/MxNSrU

By:   Mary T Zama1, Mardieh Dennis1*, Jessica Price1 and Stephanie M Topp23
1Population Council, Private Bag 319X, Ridgeway, Lusaka, Zambia
2Centre for Infectious Disease Research in Zambia, PO Box 34681, Lusaka, Zambia
3Nossal Institute for Global Health, University of Melbourne, Level 4, 161 Barry Street, Alan Gilbert Building, Carlton 3010, VIC, Australia
  

Saturday, October 24, 2015

Medical Care Following Multiple Perpetrator Sexual Assault: A Retrospective Review

This paper describes the healthcare needs of victims of multiple perpetrator sexual assault (MPSA) and single perpetrator sexual assault (SPSA) presenting to the Haven sexual assault referral centre in south-east London, and aims to identify any characteristics that might be related to attendance at follow-up appointments. 

We reviewed standardised case notes of 136 MPSA victims and 139 SPSA victims attending for forensic medical examination (FME) between 1 July 2005 and 31 July 2009. MPSA victims reported 
  • a higher rate of stranger assaults, 
  • higher rates of vaginal, anal and oral rapes, 
  • more rapes at multiple anatomical sites 
  • or multiple rapes and were more likely to sustain injuries, 
  • all of which put MPSA victims at higher risk of subsequent health problems. 
Rates of attendance at follow-up appointments were low for all (53.5%) as were rates of completion of post-exposure prophylaxis (PEP) for HIV (33.3%). Attendance at follow-up was associated with presence of anogenital injury at the time of FME. Those over the age of 30 years were less likely to attend.

Purchase full article at: http://goo.gl/1TpnTk

  • 1Haven Camberwell, King's College Hospital NHS Foundation Trust, London, UK louise.1.morgan@kcl.ac.uk.
  • 2Haven Camberwell, King's College Hospital NHS Foundation Trust, London, UK.  


Saturday, September 26, 2015

Characteristics, Medical Management & Outcomes of Survivors of Sexual Gender-Based Violence, Nairobi, Kenya

Survivors attending the clinic increased from seven in 2007 to 866 in 2011. 
  • Of the 866 survivors included, 
    • 92% were female, 
    • 34% were children and 
    • 54% knew the aggressor; 
  • 73% of the assaults occurred inside a home and most commonly in the evening or at night. 
  • Post-exposure prophylaxis for HIV was given to 536 (94%), prophylaxis for sexually transmitted infections to 731 (96%) and emergency contraception to 358 (83%) eligible patients. 
  • Hepatitis B and tetanus toxoid vaccinations were given to 774 survivors, but respectively only 46% and 14% received a second injection. 
  • Eight (4.5%) of 174 women who underwent urine pregnancy testing were positive at 1 month. 
  • Of 851 survivors HIV-tested at baseline, 
    • 96 (11%) were HIV-positive. 
    • None of the 220 (29%) HIV-negative individuals who returned for repeat HIV testing after 3 months was positive.

Acceptable, good quality sexual gender-based violence (SGBV) medical care can be provided in large cities of sub-Saharan Africa, although further work is needed to improve follow-up interventions.


Below:  Number of SGBV survivors attending the Médecins Sans Frontières clinic of Mathare, Nairobi, Kenya, between 2007 and 2011. SGBV = sexual gender-based violence.


TABLE 1

Characteristics of survivors of SGBV and description of episodes of sexual violence stratified by age group among those seeking care, Médecins Sans Frontières Clinic, Mathare, Nairobi, Kenya*
CharacteristicAge < 14 yearsAge 14–17 yearsAge ≥18 yearsTotal
n (%)n (%)n (%)n (%)
All survivors292 (34)190 (22)380 (44)866 (100)
Sex
 Female256 (88)183 (96)351 (92)792 (92)
 Male36 (12)7 (4)29 (8)72 (8)
Type of aggressor
 Relative38 (14)15 (8)11 (3)64 (8)
 Known civilian162 (59)103 (56)120 (32)385 (46)
 Unknown civilian75 (27)63 (34)238 (64)378 (45)
 Military or police3 (2)1 (<1)4 (<1)
 Unknown1761035
Number of aggressors
 1266 (93)148 (81)229 (60)645 (77)
 2–420 (7)29 (16)118 (31)168 (20)
 ≥55 (3)20 (9)25 (3)
 Unknown6828
Place of aggression
 Living space at home194 (82)147 (84)195 (61)539 (73)
 Public place15 (6)14 (8)63 (20)92 (12)
 Work place2 (1)2 (1)10 (3)14 (2)
 School12 (5)2 (1)1 (< 1)15 (2)
 Other13 (6)11 (6)53 (16)77 (11)
 Unknown561458129
Time of aggression
 00.00–06.0014 (8)14 (13)74 (25)102 (18)
 06.00–12.0019 (12)10 (9)23 (8)52 (9)
 12.00–18.0077 (46)30 (28)46 (16)154 (27)
 18.00–24.0057 (34)54 (50)148 (51)261 (46)
 Unknown1258289297
*Of the 866 survivors, 4 were of unknown age, all female: aggressors were unknown civilians for 2 and unknown for 2; number of aggressors was one for 2 survivors, four for 1 and unknown for 1. The place of assault was in the home for 3 survivors and unknown for one.
SGBV = sexual gender-based violence.

Read full article at:  http://ht.ly/SI08W 


1Médecins Sans Frontières (MSF) France, Nairobi, Kenya

Wednesday, July 29, 2015

Pre-Exposure Prophylaxis for Men and Transgender Women Who Have Sex with Men in Brazil: Opportunities and Challenges

Below:  The cascade of HIV care in Brazil in 2013



Below:  Number of individuals receiving non-occupational post-exposure prophylaxis (nPEP) from 2012 to 2014




Key aspects of the AIDS epidemic among MSM and TGW in Brazil and the comprehensive Brazilian response to the epidemic are presented. The universal access to health care provided through the Brazilian Unified Health System (SUS) and the range of prevention and care services already available countrywide to HIV-positive individuals and at-risk MSM and TGW are identified as the main facilitators for the implementation of PrEP. Limited PrEP awareness among MSM, TGW and health care providers, low HIV testing frequency and low HIV risk perception among MSM and TGW represent the core challenges to be addressed. Data generated by demonstration projects in Brazil will provide an important contribution to PrEP rollout in Brazil.

The implementation of PrEP in Brazil is feasible. A synergistic rollout of treatment as prevention and PrEP will maximize public health and individual benefits of the country's comprehensive response to the AIDS epidemic.

Read more at: ht.ly/Q5yZl HT @fiocruz