Asymptomatic Anal Sexually Transmitted Infections in HIV-Positive Men Attending Anal Cancer Screening
BACKGROUND:
HIV-positive
men who have sex with men (HIV+MSM) have an increased risk for anal dysplasia
and for sexually transmitted infections (STIs).
OBJECTIVES:
We
determined the positivity rate of Chlamydia trachomatis (CT), Neisseria
gonorrhoea (NG), Mycoplasma genitalium (MG) and syphilis in HIV+MSM
participating in an anal cancer screening (ACS)-program.
METHODS:
852
intraanal swabs were collected from 503 HIV+MSM between 2012 and 2014. Anal
cytology and PCR-assays for human papillomavirus (HPV)-, CT-, NG- and MG-detection
were performed. The syphilis status was determined serologically. Risk factors
for STIs were explored by multiple logistic regression analysis.
RESULTS:
20.7%
(104/503) of the patients had a STI other than HPV within the study period. CT
was found in 10.9%, followed by NG (8.9%), and MG (4.2%). Early syphilis was
detected in 4.6% and past syphilis in 44.5% of the HIV+MSM. 18 patients (3.6%)
had more than one STI episode. 90.6% of the 127 STI cases were asymptomatic.
Age, anal HPV infection, abnormal anal cytology, and previous syphilis were
risk factors for STI.
CONCLUSIONS:
Anal
STIs are frequent and mostly asymptomatic in HIV+MSM participating in ACS.
STI-screening should be incorporated in ACS-programs for HIV+MSM. This article
is protected by copyright. All rights reserved.
- 1Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
- 2Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Kerpener Str. 62, 50924, Koeln, Germany.
- 3Institute of Cytology, Koblenzer Strasse 121 - 123, 53177, Bonn, Germany.
- 4National Reference Center for Papilloma- and Polyomaviruses, Institute of Virology, Uniklinik Köln, University of Cologne, Fuerst-Pueckler-Str. 56, 50935, Koeln, Germany.
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