Saturday, March 5, 2016

A Finger-Stick Whole-Blood HIV Self-Test as an HIV Screening Tool Adapted to the General Public

In 2013, the French Health Authority approved the use of HIV self-tests in pharmacies for the general public. This screening tool will allow an increase in the number of screenings and a reduction in the delay between infection and diagnosis, thus reducing the risk of further infections. We previously compared 5 HIV-self test candidates (4 oral fluid and one whole blood) and demonstrated that the whole blood HIV test exhibited the optimal level of performance (sensitivity/specificity). We studied the practicability of an easy-to-use finger-stick whole blood HIV self-test “autotest VIH®”, when used in the general public.

Methods and Materials
This multicenter cross-sectional study involved 411 participants from the Parisian region (AIDES and HF association) between April and July 2014 and was divided into 2 separate studies: one evaluating the capability of participants to obtain an interpretable result using only the information notice, and a second evaluating the interpretation of test results, using a provided chart.

A total of 411 consenting participants, 264 in the first study and 147 in the second, were included. All participants were over 18 years of age. In the first study, 99.2% of the 264 participants correctly administered the auto-test, and 21.2% needed, upon their request, telephone assistance. Ninety-two percent of participants responded that the test was easy/very easy to perform, and 93.5% did not find any difficulty obtaining a sufficient good quantity of blood. In the second study, 98.1% of the 147 participants correctly interpreted the results. The reading/interpretation errors concerned the negative (2.1%) or the indeterminate (3.3%) auto-tests.

The success rate of handling and interpretation of this self-test is very satisfactory, demonstrating its potential for use by the general public and its utility to increase the number of opportunities to detect HIV patients.

Below:  Ability of participants to read and interpret the HIV self-test results using a chart from a panel of 6 standardized tests

Full article at:

Dimitrios Paraskevis, Editor
1Department of Infectious Diseases, Centre Hospitalier Régional, Orléans, France
2HF Prevention, Trappes, France
3Aides, Paris, France
4Department of Infectious Diseases, Hôpital Universitaire Bichat Claude Bernard, Paris, France
5Centre de Biologie du Chemin Vert (CBCV), Paris, France
6INSERM INED, U822, Hôpital Kremlin Bicêtre, Le Kremlin-Bicêtre, France
7Department of Infectious Diseases, Hôpital Tenon, Paris, France
University of Athens, Medical School, GREECE
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: TP SK JA GK JML JPT GP. Performed the experiments: SK JA GK EB. Analyzed the data: JPT SK TP GP. Contributed reagents/materials/analysis tools: TP CG GK EB GP. Wrote the paper: TP CG EB GP.

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