Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample
HIGHLIGHTS
- Multi-substance
use disorder was more prevalent than single use disorder.
- Alcohol
was the most common drug followed by stimulants and cannabis.
- Multi-substance
use disorder was more severe and had greater co-morbidity.
BACKGROUND:
Alcohol
and other substance use disorders (SUD) pose major problems of morbidity and
mortality in some American Indian communities, but little is known about the
clinical characteristics, risk factors, and consequences of combined alcohol
and other substance use disorders (multi-substance use disorder, MSUD) in those
communities.
METHODS:
Using the
Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), in a
community sample of 876 American Indians, the clinical characteristics of
lifetime DSM-5 moderate or severe alcohol use disorder alone (AUD alone)
(n=146) and MSUD (defined as alcohol and ≥1 other SUD) (n=284) were evaluated
and compared to 347 participants with no lifetime SUD (no SUD).
RESULTS:
The
majority (57%) of participants with a SUD had multi-substance use disorder and
94% of those were with AUD. Stimulants (cocaine and/or amphetamine) and/or
cannabis were the most common other SUDs. Participants with AUD alone were more
likely to be male and have an earlier age of first alcohol intoxication than
those with no SUD. Those with MSUD were more likely to have dropped out of high
school, have antisocial personality disorder (ASPD) or conduct disorder (CD),
have earlier ages of first alcohol intoxication and first use of cannabis and
stimulants, an earlier age of onset of AUD, and more of several AUD symptoms
than those with AUD alone, but the same temporal course and time to remission
of AUD.
CONCLUSIONS:
MSUD
is prevalent in this sample, is associated with multiple comorbidities and
denotes a more severe alcohol syndrome than AUD alone.
- 1Molecular and Cellular Neuroscience Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
- 2Molecular and Cellular Neuroscience Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: cindye@scripps.edu.
- Drug Alcohol Depend. 2016 Apr 1;161:222-9. doi: 10.1016/j.drugalcdep.2016.02.006. Epub 2016 Feb 8.
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