Showing posts with label Alcohol Intoxication. Show all posts
Showing posts with label Alcohol Intoxication. Show all posts

Thursday, April 14, 2016

Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample

HIGHLIGHTS
  • Multi-substance use disorder was more prevalent than single use disorder.
  • Alcohol was the most common drug followed by stimulants and cannabis.
  • Multi-substance use disorder was more severe and had greater co-morbidity.

BACKGROUND:
Alcohol and other substance use disorders (SUD) pose major problems of morbidity and mortality in some American Indian communities, but little is known about the clinical characteristics, risk factors, and consequences of combined alcohol and other substance use disorders (multi-substance use disorder, MSUD) in those communities.

METHODS:
Using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), in a community sample of 876 American Indians, the clinical characteristics of lifetime DSM-5 moderate or severe alcohol use disorder alone (AUD alone) (n=146) and MSUD (defined as alcohol and ≥1 other SUD) (n=284) were evaluated and compared to 347 participants with no lifetime SUD (no SUD).

RESULTS:
The majority (57%) of participants with a SUD had multi-substance use disorder and 94% of those were with AUD. Stimulants (cocaine and/or amphetamine) and/or cannabis were the most common other SUDs. Participants with AUD alone were more likely to be male and have an earlier age of first alcohol intoxication than those with no SUD. Those with MSUD were more likely to have dropped out of high school, have antisocial personality disorder (ASPD) or conduct disorder (CD), have earlier ages of first alcohol intoxication and first use of cannabis and stimulants, an earlier age of onset of AUD, and more of several AUD symptoms than those with AUD alone, but the same temporal course and time to remission of AUD.

CONCLUSIONS:
MSUD is prevalent in this sample, is associated with multiple comorbidities and denotes a more severe alcohol syndrome than AUD alone.

Purchase full article at:   http://goo.gl/ma2Rmk

  • 1Molecular and Cellular Neuroscience Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • 2Molecular and Cellular Neuroscience Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: cindye@scripps.edu.
  •  2016 Apr 1;161:222-9. doi: 10.1016/j.drugalcdep.2016.02.006. Epub 2016 Feb 8. 



Wednesday, March 2, 2016

Prevalence of Binge Drinking & Associated Behaviours among 3,286 College Students in France

BACKGROUND:
Studies conducted on characteristics of binge drinking and associated behaviours in college student populations are scarce especially in France. Hence, it is important to identify risk factors for binge drinking at university, especially those which may be changed. The aim of this study was to assess the prevalence of binge drinking and associated behaviours across a large sample of college students in Upper Normandy (France).

METHODS:
A cross sectional study was performed between November 2009 and February 2013 and data on socioeconomic characteristics and behavioural risk factors were collected: alcohol (consumption and misuse of alcohol, occasional and frequent binge drinking), tobacco, cannabis, cyberaddiction, stress and depression. An anonymous self-administered questionnaire was filled out by college student volunteers from Upper Normandy (France) either online or by paper questionnaire. Analyses were performed using multivariate logistic regression models.

RESULTS:
A total of 3286 students were included. The mean (Standard Deviation (SD)) age of students was 20.8 years (SD = 2.1) with a male-female ratio of 0.60. The prevalence of binge drinking in the never, occasional and frequent categories was respectively 34.9 %, 51.3 %, and 13.8 %. The mean number of units of alcohol consumed per week (except BD episodes) was 0.78 for never, 3.7 for occasional and 10.5 for frequent binge drinkers (p < 0.0001). A positive relation was observed between frequent binge drinking and the following: male gender, living in rented accommodation, attending business school, regular practice of sport, smoking, occasional cannabis use, and alcohol abuse. A negative association was observed between frequent binge drinking and grant holder status, living in couples, and stress.

CONCLUSIONS:
This study highlights the spread of binge drinking among college students and identifies student populations at risk: male gender, living in rented accommodation, regular practice of sport, and other risk behaviours such as use of tobacco, cannabis and alcohol. These behaviours increase with the frequency of binge drinking.

Below:  Frequency of consumption of binge drinking according to the gender of college students (France; 2010-2012) (N=3286)



Full article at:   http://goo.gl/xH28Bs

  • 1Rouen University Hospital, Clinical Investigation Center 1404, 1 Rue de Germont, Rouen Cedex, 76031, France. marie-pierre.tavolacci@chu-rouen.fr.
  • 2Rouen University Hospital, IRIB, Inserm U1073, Rouen, France. marie-pierre.tavolacci@chu-rouen.fr.
  • 3Rouen University Hospital, Clinical Investigation Center 1404, 1 Rue de Germont, Rouen Cedex, 76031, France.
  • 4Department of Nutrition, Rouen University Hospital, Rouen, France.
  • 5Department of Preventive Medicine of University, Rouen University, Rouen, France.
  • 6Rouen University Hospital, IRIB, Inserm U1073, Rouen, France.
  • 7Department of Epidemiology and Health Promotion, Rouen University Hospital, Rouen, France. 
  •  2016 Feb 23;16(1):178. doi: 10.1186/s12889-016-2863-x.



Sunday, February 28, 2016

Booze, Bars, and Bystander Behavior: People Who Consumed Alcohol Help Faster in the Presence of Others

People help each other less often and less quickly when bystanders are present. In this paper, we propose that alcohol consumption could attenuate or reverse this so-called bystander effect. Alcohol impairs people cognitively and perceptually, leading them to think less about the presence of others and behave less inhibited. Moreover, alcohol makes people more prone to see the benefits of helping and not the costs. 

To provide an initial test of these lines of reasoning, we invited visitors of bars in Amsterdam to join our study at a secluded spot at the bar. We manipulated bystander presence, and at the end of the study, we measured alcohol consumption. When participants took their seats, the experimenter dropped some items. We measured how many items were picked up and how quickly participants engaged in helping. 

Results revealed that alcohol did not influence the bystander effect in terms of the amount of help given. But importantly, it did influence the bystander effect in terms of response times: people who consumed alcohol actually came to aid faster in the presence of others.

…The foremost finding from the current contribution is that alcohol does not simply attenuate the entire bystander effect, but only increases response speeds. This could imply that the influences that seriously undermine helping and intervention (such as audience inhibition, confusion and diffusion of responsibility, and pluralistic ignorance) may slow down the decision process but do not actually change it. Indeed, people under the influence of alcohol in the presence of others were at least as fast as sober people who were alone. It seems that the complications caused by the presence of bystanders in the five-step model () may simply be ignored by them. Under the influence of alcohol, people may not notice that no-one is helping and thus do not experience pluralistic ignorance before step 2. They may not think that someone else will provide help and thus may not experience diffusion of responsibility before step 3, and they may not worry about how to implement the help in step 4. Because the amount of help given remains the same, it may imply that people make their decision to act rather quickly based on the immediate situation, and then contemplate and search (in each step) for information that confirms the correctness of the decision. As drunk people are often cognitively impaired, they may be less likely to go through this process of “false deliberation” (see also )…

Full article at:  http://goo.gl/jNLZQD

1Department of Experimental and Applied Psychology, VU University Amsterdam, Amsterdam, Netherlands
2Netherlands Institute for the Study of Crime and Law Enforcement, Amsterdam, Netherlands
3Department Psychology of Conflict, Risk, and Safety, University of Twente, Enschede, Netherlands
Edited by: Jacob B. Hirsh, University of Toronto, Canada
Reviewed by: Andrew K. Littlefield, Texas Tech University, USA; Ronald Friedman, University at Albany, SUNY, USA
*Correspondence: Marco van Bommel, ln.etnewtu@lemmobnav.m




Friday, January 29, 2016

Studying Ritual & Individual Orientations to Alcohol Use: Drinking Motives & Their Connection to Intoxication in Finland in the 2000s

Background
Finland was an agricultural country until the 1960s. Thereafter, Finland modernized rapidly. Studies have postulated that as Finland becomes modernized, intoxication-oriented drinking would gradually decrease. Current studies, however, show that heavy episodic drinking has lately become more common among men and women. Simultaneously, drinking is seldom motivated by the purpose of getting drunk. The article tackles this conundrum by approaching drinking motives from a ritual and an individual perspective. We study what kinds of drinking motives currently exist in Finland, their prevalence among different population groups, how they vary by social background, and their association with intoxication.

Methods
The data were collected as part of the nationally representative Drinking Habit Survey in 2008. It consists of verbal descriptions on the most recent drinking occasion (N = 521), estimations of its blood alcohol content, and responses to pre-defined standardized motive questions related to the latest drinking occasions (N = 8732).

Results
Besides the motive ‘to get drunk’, also the motives of drinking as a ‘time-out’ ritual, ‘to get into the mood’ and ‘I drunk to brighten up’ predict a “wet” drinking occasion. Overall, Finns highlight drinking motives of sociability, relaxation, meal drinking and situational factors. The more educated orientate to their drinking more with motives that express mastery of cultural capital and individuality. The less educated and the young, again, orientate to their drinking more with motives that imply intoxication and external expectations.

Conclusions
Whereas the ritual perspective discloses what kinds of situations predict intoxication, the individual perspective reveals what kinds of individualistic orientations are associated with drunkenness. These perspectives partly speak past each other and are difficult to combine. The article proposes that situational perspective would serve as a bridge between them and enable the incorporation of results from different research traditions.

Purchase full article at:   http://goo.gl/efzLim

Affiliations
SoRAD/Centre for Social Research on Alcohol and Drugs Stockholm University, SE-10691, Stockholm, Sweden





Thursday, January 28, 2016

Alcohol Use and Firearm Violence

Although the misuse of firearms is necessary to the occurrence of firearm violence, there are other contributing factors beyond simply firearms themselves that might also be modified to prevent firearm violence. Alcohol is one such key modifiable factor. 

To explore this, we undertook a 40-year (1975-2014) systematic literature review with meta-analysis. One large group of studies showed that over one third of firearm violence decedents had acutely consumed alcohol and over one fourth had heavily consumed alcohol prior to their deaths. 

Another large group of studies showed that alcohol was significantly associated with firearm use as a suicide means. Two controlled studies showed that gun injury after drinking, especially heavy drinking, was statistically significant among self-inflicted firearm injury victims. 

A small group of studies investigated the intersection of alcohol and firearms laws and alcohol outlets and firearm violence. One of these controlled studies found that off-premise outlets selling takeout alcohol were significantly associated with firearm assault. 

Additional controlled, population-level risk factor and intervention studies, including randomized trials of which only 1 was identified, are needed. 

Policies that rezone off-premise alcohol outlets, proscribe blood alcohol levels and enhance penalties for carrying or using firearms while intoxicated, and consider prior drunk driving convictions as a more precise criterion for disqualifying persons from the purchase or possession of firearms deserve further study.

Purchase full article at:   http://goo.gl/ZIxMts

Correspondence to Dr. Charles C. Branas, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104 (e-mail: cbranas@upenn.edu).
 2016 Jan 24. pii: mxv010. 





Tuesday, January 26, 2016

The Hazard of Sharp Force Injuries: Factors Influencing Outcome

Highlights
  • This study is original since sharp force injury is rather uncommon in Norway.
  • The overall mortality rate of sharp force injury in this study was 29%.
  • Penetrating chest injury was more deadly than penetrating abdominal injury.
  • Isolated heart injury had a lethal outcome in 80% of the cases.
  • Still the outcome of sharp force injury is often random and unpredictable.
Abstract
The risk of dying from sharp force injury is difficult to ascertain. To the best of our knowledge, no study has been performed in Norway regarding mortality due to sharp force injury or factors that impact survival. Thus, the objective of the present study was to investigate and assess mortality in subjects with sharp force injury. 

This retrospective study comprises data on 136 subjects (34 female, 102 male) with suspected severe sharp force injury (self-inflicted or inflicted by others) admitted to Haukeland University Hospital between 2001 and 2010. The majority of subjects were intoxicated, and the injury was most often inflicted by a knife. The incidence of sharp force injury in Western Norway is similar to the incidence in other European countries. Almost half of the subjects with self-inflicted injury died. In cases with injury inflicted by another individual, one in five died. Mortality rates were higher in those with penetrating chest injuries than those with penetrating abdominal injuries and higher in cases with cardiac injury compared to pleural or lung injury. Sharp force injury can be fatal, but the overall mortality rate in this study was 29%. 

Factors influencing mortality rate were the number of injuries, the topographic regions of the body injured, the anatomical organs/structures inflicted, and emergency measures performed.

Below:  Ethanol and/or drugs in subjects with sharp force injury



Below:  Number of sharp force injuries, related to outcome



Below:  Distribution of sharp force injury in surviving and deceased subjects, related to anatomical regions (both penetrating and non-penetrating injuries)


Below:  Number of surviving and deceased subjects with penetrating sharp force injury



Full article at:   http://goo.gl/q2OIUT

  • 1Department of Pathology, The Gade Institute, Haukeland University Hospital, 5021 Bergen, Norway; Department of Clinical Medicine, Gade Laboratory of Pathology, University of Bergen and Haukeland University Hospital, 5021 Bergen, Norway. Electronic address: stine.kristoffersen@helse-bergen.no.
  • 2Cand.Med.-Degree Programme, Faculty of Medicine and Dentistry, University of Bergen, Norway.
  • 3Department of Pathology, The Gade Institute, Haukeland University Hospital, 5021 Bergen, Norway; Department of Clinical Medicine, Gade Laboratory of Pathology, University of Bergen and Haukeland University Hospital, 5021 Bergen, Norway.
  • 4Department of Anaesthesia and Intensive Care, Haukeland University Hospital, 5021 Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway. 




Saturday, January 9, 2016

Women's Sex-Related Dissociation: The Effects of Alcohol Intoxication, Attentional Control Instructions, and History of Childhood Sexual Abuse

This study examined influences of alcohol intoxication, attentional control, and CSA severity on sex-related dissociation. Sex-related dissociation is defined here as dissociation (e.g., feeling as if the world is unreal and feeling disconnected from one's body) during sexual activity or in the presence of sexual stimuli. 

Women (N = 70) were randomized to a 2 (alcohol condition: none, .10% peak breath alcohol concentration) x 2 (attentional control instructions: none, "relax and maximize" sexual arousal) experiment and exposed to sexual stimuli. 

Alcohol intoxication was positively associated with sex-related dissociation. CSA severity and sex-related dissociation were positively associated in the no instruction condition but not in the "relax and maximize" condition. 

For some women, efforts to relax and maximize sexual arousal may buffer the association between CSA and sex-related dissociation.
  
Purchase full article at:   http://goo.gl/1HdGCF

  • 1 University of Washington, Psychology , Seattle , United States.
  • 2 Medical University of South Carolina , Department of Psychiatry & Behavioral Science , Charleston , United States.
  • 3 University of Washington, Psychiatry , Seattle , United States.
  • 4 Indiana University and the Kinsey Institute, Psychological & Brain Sciences , Bloomington , United States.
  • 5 University of Washington, School of Social Work , Seattle , United States.
  • 6 University of Washington, Alcohol and Drug Abuse Institute , Seattle , United States.
  •  2016 Jan 6:0.  



Monday, January 4, 2016

Vitamin C Deficiency of Korean Homeless Patients Visiting to Emergency Department with Acute Alcohol Intoxication

Vitamins are essential micronutrients for maintenance of tissue functions. Vitamin deficiency is one of the most serious and common health problems among both chronic alcoholics and the homeless. However, the vitamin-level statuses of such people have been little studied. We evaluated the actual vitamin statuses of alcoholic homeless patients who visited an emergency department (ED). 

In this study the blood levels of vitamins B1, B12, B6, and C of 217 alcoholic homeless patients were evaluated retrospectively in a single urban teaching hospital ED. Vitamin C deficiency was observed in 84.3% of the patients. The vitamin B1, B12, and B6 deficiency rates, meanwhile, were 2.3%, 2.3%, and 23.5%, respectively. Comparing the admitted patients with those who were discharged, only the vitamin C level was lower. (P=0.003) In fact, the patients' vitamin C levels were markedly diminished, vitamin C replacement therapy for homeless patients should be considered in EDs.

Below:  Scatter plots of blood levels of vitamins. The lower lines represent lower-normal levels, and the upper lines, upper-normal levels.



Full article at:   http://goo.gl/6a3CF5

Department of Emergency Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.
corresponding authorCorresponding author.
Address for Correspondence: Jonghwan Shin, MD. Department of Emergency Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20 Boramae-5-gil, Dongjak-gu, Seoul 07061, Korea. Tel: +82.2-870-2662, Fax: +82.2-831-2826, Email:moc.revan@renihsyks
J Korean Med Sci. 2015 Dec; 30(12): 1874–1880.
Published online 2015 Nov 30. doi:  10.3346/jkms.2015.30.12.1874