Higher HIV RNA Viral Load in Recent Patients with Symptomatic Acute HIV Infection in Lyon University Hospitals
INTRODUCTION:
Increased
human immunodeficiency virus (HIV) virulence at infection has been suggested by
a meta-analysis based on viral load and CD4 T lymphocytes (CD4) count during
acute infection. This result was obtained after secondary analyses of large
databases, facilitating the detection of differences. Similar finding in
cohorts of more modest sample size would indicate that the effect could be more
substantial.
METHODS:
Change
from initial CD4 count and HIV viral load after acute HIV infection by calendar
year was explored in patients treated at Lyon University hospitals. All
patients admitted to our hospitals with acute HIV infection between 1996 and
2013 were included in our study. Initial CD4 count and viral load before the
start of anti-retroviral treatment were analyzed. Trends over time were
assessed in linear models.
RESULTS:
Initial
CD4 count remained similar over time. However, in 2006-2013, initial viral load
rose significantly (+1.12 log10/ml/year, p = 0.01).
CONCLUSION:
Our
data, obtained from a single hospital cohort, confirmed findings from a large
meta-analysis, showed increased initial viremia at acute HIV infection since
2006 and suggesting potentially higher HIV virulence in recent years.
Below: Initial viral load during acute HIV infection by year, Lyon university Hospitals, 1996 to 2013
- 1Infection Control and Epidemiology Unit, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
- 2Department of Infectious Diseases, Hospices Civils de Lyon, Lyon, France.
- 3Infection Control and Epidemiology Unit, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
- 4Emerging Pathogens Laboratory, Fondation Mérieux, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon, 69007, France.
- PLoS One. 2016 Jan 22;11(1):e0146978. doi: 10.1371/journal.pone.0146978. eCollection 2016.
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