Showing posts with label Transgender Women. Show all posts
Showing posts with label Transgender Women. Show all posts

Wednesday, April 13, 2016

Descriptive Epidemiology of Factors Associated with Human Immunodeficiency Virus Infections among Men and Transgender Women Who Have Sex with Men in South India

PURPOSE:
Men and transgender women who have sex with men (MTWSM) continue to be an at-risk population for human immunodeficiency virus (HIV) infection in India. Identification of risk factors and determinants of HIV infection is urgently needed to inform prevention and intervention programming.

METHODS:
Data were collected from cross-sectional biological and behavioral surveys from four districts in Karnataka, India. Multivariable logistic regression models were constructed to examine factors related to HIV infection. Sociodemographic, sexual history, sex work history, condom practices, and substance use covariates were included in regression models.

RESULTS:
A total of 456 participants were included; HIV prevalence was 12.4%, with the highest prevalence (26%) among MTWSM from Bellary District. In bivariate analyses, district (P = 0.002), lack of a current regular female partner (P = 0.022), and reported consumption of an alcoholic drink in the last month (P = 0.004) were associated with HIV infection. In multivariable models, only alcohol use remained statistically significant (adjusted odds ratios: 2.6, 95% confidence intervals: 1.2-5.8; P = 0.02).

CONCLUSION:
The prevalence of HIV continues to be high among MTWSM, with the highest prevalence found in Bellary district.

Purchase full article at:   http://goo.gl/LWpwVn

  • 1 Department of Community Health Sciences, Centre for Global Public Health, University of Manitoba , Winnipeg, Manitoba, Canada .
  • 2 Karnataka Health Promotion Trust , Bangalore, India .
  • 3 Department of Medicine, University of Toronto , Toronto, Ontario, Canada .
  • 4 Department of Medical Microbiology, University of Nairobi , Nairobi, Kenya .
  • 5 St. John's Research Institute , Bangalore, India .
  • 6 Department of Medical Microbiology, University of Manitoba , Winnipeg, Manitoba, Canada .
  •  2016 Apr 8. [ 



Friday, April 1, 2016

'HIV and work don't go together': Employment as a social determinant of HIV outcomes among men who have sex with men and transgender women in the Dominican Republic

Men who have sex with men (MSM) and transgender women are disproportionately affected by HIV in the Dominican Republic. Little is known about their experiences living with HIV as a chronic condition. 

We explored employment as a social determinant of well-being with HIV. We conducted 42 qualitative in-depth interviews with MSM (n = 16) and transgender women (n = 5) living with HIV; each participant completed 2 interviews to facilitate depth and iterative analysis. We used narrative analysis and systematic coding to identify salient themes related to employment and the HIV experience and developed a conceptual model of the pathways between HIV stigma, unemployment, and HIV outcomes. Early life experiences, including rejection from families and school, resulted in limited work opportunities, especially among transgender women. Following HIV diagnosis, participants across all socio-economic levels lost jobs and/or were unable to get jobs due to illegal HIV testing and HIV stigma and discrimination. Not being able to work impacted mental health, engagement in HIV care, and overall well-being. 

We conclude that lack of employment is a salient concern among MSM and transgender women living with HIV. Holistic, multi-level programmes that address illegal HIV testing and discriminatory hiring practices are urgently needed to facilitate engagement in care and long-term well-being.

Purchase full article at:   http://goo.gl/xEjW71

  • 1 Department of Health Behavior, Gillings School of Global Public Health , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
  • 2 Consejo Nacional para el VIH y el SIDA , Santo Domingo , Dominican Republic.
  • 3 HIV Vaccine Research Unit, Instituto Dermatalógico y Cirugía de Piel Dr. Huberto Bogaert Díaz , Santo Domingo , Dominican Republic.
  • 4 Department of Health, Behavior, and Society , Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA. 
  •  2016 Mar 21:1-16. 



Sunday, March 27, 2016

Breast Cancer in a Male to Female Transsexual Patient with a BRCA2 Mutation

Breast cancer is rare in male patients. Certain predisposing factors, be they genetic (e.g. BRCA2 gene mutations) or hormonal (imbalance between estrogen and androgen levels) have been implicated in male breast cancer pathophysiology. 

Male to female (MtF) transsexualism is a condition that generally involves cross-sex hormone therapy. Anti-androgens and estrogens are used to mimic the female hormonal environment and induce the cross-sex secondary characteristics. In certain situations, the change of the hormonal milieu can be disadvantageous and favor the development of hormone-dependent pathologies, such as cancer. 

We report a case of a MtF transgender (TG) patient who developed breast cancer after seven years of cross-sex hormonal therapy. The patient was found to be BRCA2 positive, and suffered recurrent disease. The patient was unaware of being a member of an established BRCA2 mutation positive kindred. 

This represents the first case of a BRCA2 mutation predisposing to breast cancer in a MtF transgender patient.

Purchase full article at:   http://goo.gl/4SsOEP

By:  Corman V1, Potorac I2, Manto F3, Dassy S4, Segers K5, Thiry A6, Bours V7, Daly AF8, Beckers A9.
  • 1V Corman, Department of Endocrinology, CHU de Liege, Liege, Belgium.
  • 2I Potorac, Department of Endocrinology, CHU de Liege, Liege, 4000, Belgium.
  • 3F Manto, Faculty of Medicine, University of Liege, Liege, Belgium.
  • 4S Dassy, Department of Oncology, St. Nikolaus-Hospital, Eupen, Belgium.
  • 5K Segers, Department of Human Genetics, CHU de Liege, University of Liege, Liege, Belgium.
  • 6A Thiry, Department of Anatomo-pathology, CHU de Liege, Liege, Belgium.
  • 7V Bours, Department of Human Genetics, CHU de Liege, University of Liege, Liege, Belgium.
  • 8A Daly, Department of Endocrinology, University of Liège, Liège, Belgium.
  • 9A Beckers, Department of Endocrinology, Domaine Universitaire du Sart-Tilman, CHU de Liege, Liege, Belgium albert.beckers@chu.ulg.ac.be.
  •  2016 Mar 21. pii: ERC-16-0057




Saturday, March 26, 2016

Symptomatic HPV-Related Neovaginal Lesions in Transgender Women: Case Series & Review of Literature

OBJECTIVE:
Worldwide, transgender women are an at-risk population for contracting sexually transmitted infections. Little information exists on symptoms and characteristics of neovaginal human papillomavirus (HPV) infections and associated diseases. We describe a case series of transgender women with symptomatic HPV-related neovaginal lesions and a review of current literature.

METHODS:
Transgender women with symptomatic HPV-related neovaginal lesions were identified from a departmental database comprising clinical and outpatient data on transgender women who underwent vaginoplasty between 1990 and 2015. HPV status was determined on excision and biopsy specimens by HPV DNA testing using GP5+6+-PCR and p16INK4A immunohistochemistry. Current literature was reviewed using the MEDLINE and EMBASE databases.

RESULTS:
This case series includes four transgender women with symptomatic, HPV-related neovaginal lesions. Two women presented with neovaginal and neovulvar pain and condylomata/leukoplakia, which were excised. These lesions showed moderate-to-severe dysplasia at histopathological examination, and were positive for high-risk HPV (hrHPV) and p16INK4A. Recurrence occurred in one patient and was treated with laser evaporation. Two women presented with neovaginal coital pain, neovaginal bleeding and condylomata. Neovulvar lesions were treated with podophyllotoxin. Neovaginal lesions were excised or evaporated. These lesions were low-risk HPV (lrHPV) positive. The literature search shows treatment options varying from conservative, topical podophyllotoxin to excision or laser evaporation under general anaesthesia.

CONCLUSIONS:
Neovaginal HPV infection can lead to benign condylomata (lrHPV) and various grades of dysplasia (hrHPV). We advise physicians to consider HPV infection and associated lesions in transgender women with otherwise unexplainable neovaginal pain or bleeding after vaginoplasty.

Purchase full article at:   http://goo.gl/9XZIBN

  • 1Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands EMGO+Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands.
  • 2Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands EMGO+Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands Centre of Expertise on Gender Dysphoria, VU University Medical Centre, Amsterdam, The Netherlands.
  • 3Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands. 
  •  2016 Mar 24. pii: sextrans-2015-052456. doi: 10.1136/sextrans-2015-052456.



Wednesday, March 16, 2016

The Role of the Illusion in the Construction of Erotic Desire: Narratives from Heterosexual Men Who Have Occasional Sex with Transgender Women

Little is known about men's sexual desire for and erotic attraction to male-to-female transgender women. To better understand how erotic desire is constructed, this study examined the narratives of a sample of heterosexual men who had had an occasional sexual encounter with a transgender woman. 

Open-ended qualitative interviews were conducted with 16 heterosexual men who reported at least one sexual encounter with a transgender woman in the previous 12 months. Using principles of Grounded Theory, three themes emerged: 
  1. the erotic desire that transpired from a transgender woman's construction of her femininity, 
  2. the sexual act that dictated the specific navigation of a transgender woman's penis and 
  3. the sexual dissonance that resulted from being a heterosexually identified man having sex with a partner who had a penis. 
These themes reflected how the participants defined and negotiated their sexual encounters, both psychologically through their understanding of sex with a transgender woman with a penis, and physically through the navigation of specific sex acts. 

The role of the 'illusion' was central to the meaning and construction of erotic desire. These narratives provided another framework for continuing discourse on the complexity of erotic desire.

Purchase full article at:   http://goo.gl/ruljKP

  • 1 Friends Research Institute, Inc. , Los Angeles , USA.
  • 2 Integrated Substance Abuse Programs, Semel Institute for Neuroscience and Human Behavior , University of California at Los Angeles , California , USA.
  • 3 Department of Obstetrics, Gynecology and Reproductive Sciences; Bixby Center for Global Reproductive Health , University of California at San Francisco , San Francisco , USA.
  • 4 Department of Philosophy , California State University , Los Angeles , USA. 
  •  2016 Mar 11:1-13. 



Wednesday, March 9, 2016

Examining the Sociocultural Context of HIV-related Risk Behaviors among Kathoey (Male-to-female Transgender Women) Sex Workers in Bangkok, Thailand

Kathoey (male-to-female transgender) sex workers (KSW) in Thailand are at high risk for sexually transmitted infections; however, few qualitative studies have been conducted to understand the sociocultural context of engaging in HIV risk behaviors. 

A total of 24 participants were purposively sampled in Bangkok based on KSW work venues and substance use. Results revealed the importance of participants' understanding of the self in relation to establishing economic independence through sex work, which could then be used to re-establish support from family, who often have not accepted a son's gender transition. 

Participants linked being kathoey to a belief in fate but did not view engagement in sex work in the same way. Different sex work venues exposed KSW to different risky situations. 

HIV prevention programs for kathoey must address the importance of economic security and its relation to social support and gender transition within a cultural- and work-environment-specific framework.

Purchase full article at:   http://goo.gl/29IV2g

 2016 Mar-Apr;27(2):153-65. doi: 10.1016/j.jana.2015.11.003. Epub 2015 Nov 14.




Sunday, March 6, 2016

Staying in the Hood: Black Lesbian and Transgender Women and Identity Management in North Philadelphia

The concept "Don't Ask, Don't Tell" regarding Black LGBT sexuality in Black communities has been an acceptable form of identity management for Black LGBT people. In other words, Black LGBT people are accepted as long as they are not vocal about their sexuality. However, this is changing with the issue of gay marriage, which is creating a space where Black LGBT people are more open about their gender identity/sexuality in heterosexual Black spaces. 

This new form of openness allows Black LGBT people to 'stay in' their communities, as opposed to coming out. In this article I examine how Black LGBT women in North Philadelphia stay in their communities: being politically active regarding LGBT issues, disengaging from LGBT issues, passing, and educating straight Black people about issues affecting the Black LGBT community. I conclude with implications of staying in and intersectionality among Black heterosexual and LGBT women fighting for social change.

Purchase full article at:   http://goo.gl/c5IhzS

By:  Brooks S1.
  • 1 African American Studies, California State University at Fullerton, Fullerton, California, USA. 



Wednesday, March 2, 2016

Anonymous Partnerships among MSM & Transgender Women (TW) Recently Diagnosed with HIV & Other STIs in Lima, Peru: An Individual-Level & Dyad-Level Analysis

OBJECTIVES:
Partner notification (PN) following sexually transmitted disease (STI) diagnosis is a key strategy for controlling HIV/STI transmission. Anonymous partnerships are an important barrier to PN and often associated with high-risk sexual behaviour. Limited research has examined the profile of men who have sex with men (MSM) and transgender women (TW) who engage in anonymous sex. To better understand anonymous partnership practices in Lima, Peru, we assessed participant-level and partnership-level characteristics associated with anonymous sex among a sample of MSM and TW recently diagnosed with HIV/STI.

METHODS:
MSM and TW diagnosed with HIV/STI within the past month completed a cross-sectional survey regarding anticipated PN practices. Participants reported sexual partnership types and characteristics of up to three of their most recent partners. Using a Poisson generalised estimating equation model, we assessed participant-level and partnership-level characteristics associated with anonymous partnerships.

RESULTS:
Among 395 MSM and TW with HIV/STI, 36.0% reported at least one anonymous sexual partner in the past 3 months (mean of 8.6 anonymous partners per participant; SD 17.0). Of the 971 partnerships reported, 118 (12.2%) were anonymous and the majority (84.8%) were with male partners, followed by 11.0% with female partners and 4.2% with transgender/travesti partners. Partner-level characteristics associated with increased likelihood of having an anonymous partner included female (adjusted prevalence ratio (aPR) 2.28, 95% CI 1.05 to 4.95, p=0.04) or transgender/travesti (aPR 4.03, 95% CI 1.51 to 10.78, p=0.006) partner gender.

CONCLUSIONS:
By assessing both individual-level and dyadic-level factors, these results represent an important step in understanding the complexity of partnership interactions and developing alternative PN strategies for Latin America.

Purchase full article at:   http://goo.gl/BTvxSq

  • 1Department of Sociomedical Sciences, Columbia Mailman School of Public Health, New York, USA Department of Medicine and Program in Global Health, David Geffen School of Medicine at UCLA, Los Angeles, USA.
  • 2Department of Epidemiology, Harvard School of Public Health, Boston, USA.
  • 3Department of Medicine and Program in Global Health, David Geffen School of Medicine at UCLA, Los Angeles, USA.
  • 4Asociación Civil Impacta Salud y Educación, Lima, Peru Department of Global Health, University of Washington, Seattle, USA. 
  •  2016 Feb 24. pii: sextrans-2015-052310. doi: 10.1136/sextrans-2015-052310.



Friday, February 26, 2016

Provider-Initiated HIV Testing for Migrants in Spain: A Qualitative Study with Health Care Workers and Foreign-Born Sexual Minorities

Introduction
Provider-initiated HIV testing (PITC) is increasingly adopted in Europe. The success of the approach at identifying new HIV cases relies on its effectiveness at testing individuals most at risk. However, its suitability to reach populations facing overlapping vulnerabilities is under researched. This qualitative study examined HIV testing experiences and perceptions amongst Latin-American migrant men who have sex with men and transgender females in Spain, as well as health professionals’ experiences offering HIV tests to migrants in Barcelona and Madrid.

Methods
We conducted 32 in-depth interviews and 8 discussion groups with 38 Latin-American migrants and 21 health professionals. We imported verbatim transcripts and detailed field work notes into the qualitative software package Nvivo-10 and applied to all data a coding framework to examine systematically different HIV testing dimensions and modalities. The dimensions analysed were based on the World Health Organization “5 Cs” principles: Consent, Counselling, Connection to treatment, Correctness of results and Confidentiality.

Results
Health professionals reported that PITC was conceptually acceptable for them, although their perceived inability to adequately communicate HIV+ results and resulting bottle necks in the flow of care were recurrent concerns. Endorsement and adherence to the principles underpinning the rights-based response to HIV varied widely across health settings. The offer of an HIV test during routine consultations was generally appreciated by users as a way of avoiding the embarrassment of asking for it. Several participants deemed compulsory testing as acceptable on public health grounds. In spite of—and sometimes because of—partial endorsement of rights-based approaches, PITC was acceptable in a population with high levels of internalised stigma.

Conclusion
PITC is a promising approach to reach sexual minority migrants who hold high levels of internalised stigma but explicit extra efforts are needed to safeguard the rights of the most vulnerable.

Full article at:   http://goo.gl/Xg3Hnk

  • 1ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
  • 2Centre for Social Science and Global Health, University of Amsterdam, Amsterdam, The Netherlands. 
  •  2016 Feb 25;11(2):e0150223. doi: 10.1371/journal.pone.0150223.



Tuesday, February 23, 2016

Impact of Alcohol Use on Sexual Behavior among Men Who Have Sex with Men & Transgender Women in Lima, Peru

BACKGROUND:
Alcohol use disorders (AUDs) may enhance the likelihood of risky sexual behaviors and the acquisition of sexually transmitted infections (STIs). Associations between AUDs with condomless anal intercourse (CAI) and STI/HIV prevalence were assessed among men who have sex with men (MSM) and transgender women (TW) in Lima, Peru.

METHODS:
MSM and TW were eligible to participate based on a set of inclusion criteria which characterized them as high-risk. Participants completed a bio-behavioral survey. An AUDIT score ≥8 determined AUD presence. Recent STI diagnosis included rectal gonorrhea/chlamydia, syphilis, and/or new HIV infection within 6 months. Prevalence ratios (PR) were calculated using Poisson regression.

RESULTS:
Among 312 MSM and 89 TW, 45% (181/401) had an AUD. Among those with an AUD, 164 (91%) were hazardous/harmful drinkers, and 17 (9%) had alcohol dependence. Higher CAI was reported by participants with an AUD vs. without, (82% vs. 72% albeit not significant). Reporting anal sex in two or more risky venues was associated with screening AUD positive vs. not (24% vs. 15%, p=0.001). There was no difference in recent STI/HIV prevalence by AUD status (32% overall). In multivariable analysis, screening AUD positive was not associated with CAI or recent STI/HIV infection.

CONCLUSIONS:
In our sample AUDs were not associated with CAI or new HIV infection/recent STI. However higher prevalence of CAI, alcohol use at last sex, and anal sex in risky venues among those with AUDs suggests that interventions to reduce the harms of alcohol should be aimed toward specific contexts.

Purchase full article at:   http://goo.gl/W8w5a4

  • 1Division of Infectious Diseases, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
  • 2Division of Infectious Diseases, UCLA David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: kkonda@mednet.ucla.edu.
  • 3Partners in Health, Director of Research, Lima, Peru.
  • 4Division of Infectious Diseases, Naval Medical Center San Diego, CA, USA.
  • 5Division of Clinical Sciences, Center for Healthy Communities, University of California, Riverside, CA, USA.
  • 6Unit of Health, Sexuality and Human Development, School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • 7Alberto Barton Health Center, Health Directorate of Callao, Lima, Peru. 
  •  2016 Feb 16. pii: S0376-8716(16)00060-0. doi: 10.1016/j.drugalcdep.2016.01.030.



Tuesday, February 9, 2016

HIV Self-Testing in Peru: Questionable Availability, High Acceptability But Potential Low Linkage to Care among Men Who Have Sex with Men & Transgender Women

HIV status awareness is key to prevention, linkage-to-care and treatment. Our study evaluated the accessibility and potential willingness of HIV self-testing among men who have sex with men (MSM) and transgender women in Peru. 

We surveyed four pharmacy chains in Peru to ascertain the commercial availability of the oral HIV self-test. The pharmacies surveyed confirmed that HIV self-test kits were available; however, those available were not intended for individual use, but for clinician use. 

We interviewed 147 MSM and 45 transgender women; nearly all (82%) reported willingness to perform the oral HIV self-test. However, only 55% of participants would definitely seek a confirmatory test in a clinic after an HIV-positive test result. Further, price may be a barrier, as HIV self-test kits were available for 18 USD, and MSM and transgender women were only willing to pay an average of 5 USD. 

HIV self-testing may facilitate increased access to HIV testing among some MSM/transgender women in Peru. However, price may prevent use, and poor uptake of confirmatory testing may limit linkage to HIV treatment and care.

Purchase full article at:   http://goo.gl/BcYWhj

  • 1Unit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • 2Unit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles CA, USA.
  • 3Department of Epidemiology, University of California, Los Angeles, Los Angeles, CA, USA dvoradavey@ucla.edu.
  • 4Unit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru Epicentro Salud, Lima, Peru.
  • 5Barton Health Center, Health Directorate of Callao, Lima, Peru.
  • 6Center for Healthy Communities, Division of Clinical Sciences, UCR School of Medicine, Riverside, CA USA.
  • 7Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles CA, USA Department of Epidemiology, University of California, Los Angeles, Los Angeles, CA, USA. 
  •  2016 Jan 29. pii: 0956462416630674.